Effects of caffeic acid phenethyl ester on testicular torsion/detorsion injury in rats

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dc.contributor.authorİpek, Hülya
dc.contributor.authorDoğan, Gül
dc.contributor.authorDoğan, Güvenç
dc.contributor.authorDeveci, Engin
dc.date.accessioned2019-05-13T09:08:07Z
dc.date.available2019-05-13T09:08:07Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractOBJECTIVE: To investigate the protective effect of caffeic acid phenethyl ester (CAPE) on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury. STUDY DESIGN: Thirty male Wistar albino rats were randomly categorized into 3 groups: Sham, torsiondetorsion (T/D), and T/D+CAPE. Malondialdehyde (MDA), SOD, CAT, GSH levels, histopathological damage, and expression levels of endothelin-1 and ADAM-15 were examined in testicular tissue. RESULTS: The MDA level in the T/D group testes were significantly higher than those in the sham group. MDA levels of testes were lower in the CAPE-treated group than those in the T/D group. The T/D group had significantly lower SOD, CAT, and GSH levels in the testes than did the sham group. SOD, CAT, and GSH levels of the testes were lower in the CAPE-treated group than in the T/D group. In T/D group the thickness of the basal membrane in the tubules was increased, and degeneration and apoptosis in spermatogenetic cells, organization disorder in Sertoli cells, and sperm cells in the lumen were observed. The CAPE-treated group showed less atrophy and degeneration of the tubule epithelium than did the T/D group. CONCLUSION: It has been thought that CAPE administration after T/D testis damage may affect spermatogenesis development by inducing cell-cell junction by reducing apoptotic development which can regulate blood flow and microcirculation in testes. © 2018 Science Printers and Publishers, Inc.
dc.identifier.citationİpek, H., Doğan, G., Doğan, G. Deveci, E. (2018). Effects of caffeic acid phenethyl ester on testicular torsion/detorsion injury in rats. Analytical and Quantitative Cytopathology and Histopathology, 40(6), 270-276.
dc.identifier.endpage276en_US
dc.identifier.issn0301-102X
dc.identifier.issue6en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage270en_US
dc.identifier.urihttps://hdl.handle.net/11491/1941
dc.identifier.volume40en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherScience Printers and Publishers Inc.
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCaffeic Acid Phenethyl Esteren_US
dc.subjectCaffeic Acidsen_US
dc.subjectIschemia/Reperfusion Injuryen_US
dc.subjectRaten_US
dc.subjectSpermatic Cord Torsionen_US
dc.subjectTesticular Torsionen_US
dc.subjectTestisen_US
dc.subjectTorsion Abnormalityen_US
dc.subjectTorsion of Testicular Corden_US
dc.subjectTorsion/Detorsionen_US
dc.titleEffects of caffeic acid phenethyl ester on testicular torsion/detorsion injury in rats
dc.typeArticle

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