The effects of sildenafil and tadalafil on ischemia-reperfusion injury in rat ovarian torsion model

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dc.contributor.authorToğrul, Cihan
dc.contributor.authorÇitil Doğan, Ayşe
dc.contributor.authorBaşer, Eralp
dc.contributor.authorDoğan, Murat
dc.contributor.authorAlbayrak, Aynur
dc.contributor.authorÇağlar, Mete
dc.contributor.authorGüngör, Tayfun
dc.contributor.authorÖztürk, Gülfen
dc.contributor.authorFadıllıoğlu, Ersin
dc.contributor.authorDelibaşı, Tuncay
dc.date.accessioned2019-05-13T08:57:29Z
dc.date.available2019-05-13T08:57:29Z
dc.date.issued2017
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractObjective: In cases of ovarian torsion (OT), reperfusion injury may further damage ovarian tissue. Tadalafil and sildenafil are phosphodiesterase- 5 (PDE-5) inhibitors that are primarily used for treatment of erectile dysfunction and pulmonary hypertension. In this study, the authors investigated the effects of these agents in preventing ovarian ischemia-reperfusion injury in a rat OT model. Materials and Methods: A total of 48 young adult female Wistar Albino rats were randomized into six groups (n=8 in each group); group 1: controlsham operated, group 2: sildenafil one mg/kg, group 3: tadalafil one mg/kg, group 4: sildenafil one mg/kg + ischemia/reperfusion, (I/R) two hours of ischemia and two hours of reperfusion and a single dose of oral one mg/kg sildenafil one hour before I/R, group 5: I/R, and group 6: tadalafil one mg/kg + I/R two hours of ischemia and two hours of reperfusion and a single dose of oral one mg/kg tadalafil one hour before I/R. Histopathologic evaluation was performed and scored according to the degree of congestion, edema, and hemorrhage. Total histological score (THS), tissue protein carbonyl (PC), malondialdehyde (MDA) levels, and catalase (CAT) activity were also calculated. Results: Group 4, group 5, and group 6 had similar congestion, edema and THS (p > 0.05). Group 6 had significantly lower hemorrhage score, when compared with group 5 (p = 0.03). Mean PC, MDA levels, and CAT were similar between groups 4, 5, and 6 (p > 0.05). Conclusions: Tadalafil was associated with a decreased tissue hemorrhage score in I/R injury in rat ovarian torsion model.
dc.identifier.citationTogrul, C., Dogan, A. C., Baser, E., Dogan, M., Albayrak, A., Caglar, M., ... & Delibasi, T. (2017). The effects of sildenafil and tadalafil on ischemia-reperfusion injury in rat ovarian torsion model.
dc.identifier.doi10.12891/ceog3426.2017
dc.identifier.endpage539en_US
dc.identifier.issn0390-6663
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage535en_US
dc.identifier.urihttps://doi.org/10.12891/ceog3426.2017
dc.identifier.urihttps://hdl.handle.net/11491/940
dc.identifier.volume44en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherS.O.G. CANADA Inc.
dc.relation.ispartofClinical and Experimental Obstetrics and Gynecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOvaryen_US
dc.subjectPhosphodiesterase Inhibitorsen_US
dc.subjectReperfusion Injuryen_US
dc.titleThe effects of sildenafil and tadalafil on ischemia-reperfusion injury in rat ovarian torsion model
dc.typeArticle

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