Study to Determine the Significant Prognostic Factors Related with Better Clinical Outcome in Glioblastoma Multiforme Patients

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dc.contributor.authorEryilmaz, Fahri
dc.contributor.authorRaza, Muhammad Asif
dc.date.accessioned2021-11-01T15:05:03Z
dc.date.available2021-11-01T15:05:03Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractAim: In adults glioblastoma multiforme (GBM) is the deadly and utmost communal brain tumor. GBM has poor prognosis and the median general endurance hardly surpasses one-year. In this study, we retrospectively assessed the demographic and clinical characteristics of patients with GBM and to recognize significant prognostic factors that may be associated with better results in our population. Material and Methods: The clinicopathological, treatment parameters (ie, chemotherapy, radiotherapy and the surgical resection extent) and demographic parameters were attained from medical records. SPSS version 23.0 was applied for all statistical analyzes. The overall survival and median progression-free survival was 14.1 and 10 months; correspondingly. Results: In the subjects with the longest overall survival group, a tumor was found in the frontotemporal area, and then in the frontal area. In a univariate analysis, age, co-administration of adjuvant temozolomide (TMZ) and chemoradiotherapy were prognosticators of both overall survival (OS) and progression-free survival (PFS). Though, in multivariate analysis, radiotherapy and age were important determinants of endurance. Subjects who received the cyber-knife after relapse had a lengthier operating system. Conclusion: The patients were retrospectively assessed with GBM in the facility, and the outcomes confirmed formerly testified factors influencing GBM endurance.
dc.identifier.endpage1391en_US
dc.identifier.issn1996-7195
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85100060179
dc.identifier.scopusqualityN/A
dc.identifier.startpage1389en_US
dc.identifier.urihttps://hdl.handle.net/11491/7074
dc.identifier.volume14en_US
dc.identifier.wosWOS:000619532500203
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherLahore Medical & Dental Coll
dc.relation.ispartofPakistan Journal Of Medical & Health Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectglioblastoma multiformeen_US
dc.subjectprognosisen_US
dc.subjectoverall survivalen_US
dc.subjectchemotherapyen_US
dc.subjectradiotherapyen_US
dc.subjectsurgical resectionen_US
dc.titleStudy to Determine the Significant Prognostic Factors Related with Better Clinical Outcome in Glioblastoma Multiforme Patients
dc.typeArticle

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