Validated electroanalytical and RP-LC assay of ertapenem in its pharmaceutical dosage form

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dc.contributor.authorGümüştaş, Mehmet
dc.contributor.authorKaradaş Bakırhan, Nurgül
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.date.accessioned2019-05-10T09:39:15Z
dc.date.available2019-05-10T09:39:15Z
dc.date.issued2013
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractErtapenem is a member of carbapenem group beta-lactam antibiotics. The electrochemical behavior of ertapenem at the surface on a boron-doped diamond electrode is described. It is investigated and determined using cyclic, linear sweep, differential pulse and square wave voltammetric techniques with this electrode. Two responses of ertapenem are irreversible in nature, and diffusion-controlled. A linear voltammetric response for both peaks was obtained in the concentration range of 1.0 to 12.00 µg.mL-1 for differential pulse and square wave voltammetric techniques. Also simple, accurate, precise and fully validated RP-LC assay as a comparison method of this compound in its dosage form has been developed. An X-Select RP-18 column at 25 °C was used with the mobile phase of water: methanol 55:45 (v/v) adjusted to pH 3.0. The RP-LC method allowed quantitation over the 1.0-15.00 µg.mL -1 range for ertapenem. The necessary statistical validation parameters with the system suitability test results revealed that the proposed methods are free from significant systematic errors. Degradation studies were also performed in bulk substance to demonstrate the stability indicating power with using chromatographic technique. The proposed methods successfully applied to the pharmaceutical dosage form.
dc.identifier.citationGumustas, M., Karadas, N., & Ozkan, S. A. (2013). Validated electroanalytical and RP-LC assay of ertapenem in its pharmaceutical dosage form. Revue Roumaine de Chimie, 58(7-8), 679-690.
dc.identifier.endpage690en_US
dc.identifier.issn0035-3930
dc.identifier.issue07.Augen_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage679en_US
dc.identifier.urihttps://hdl.handle.net/11491/650
dc.identifier.volume58en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherEditions de l'Academie Republique Populaire
dc.relation.ispartofRevue Roumaine de Chimie
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject[Belirlenecek]en_US
dc.titleValidated electroanalytical and RP-LC assay of ertapenem in its pharmaceutical dosage form
dc.typeConference Object

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