The Impact of PER3 VNTR Polymorphism on the Development of Schizophrenia in a Turkish Population

Basit Öğe Kaydı
dc.contributor.authorOzsoy, Filiz
dc.contributor.authorYigit, Serbulent
dc.contributor.authorNursal, Ayse Feyda
dc.contributor.authorKulu, Muberra
dc.contributor.authorKarakus, Nevin
dc.date.accessioned2021-11-01T15:06:05Z
dc.date.available2021-11-01T15:06:05Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractIntroduction: Up to 80% of patients who suffer from schizophrenia have sleep impairments, which affect physical and mental health, as well as quality of life. Several tandem repeat polymorphisms (VNTRs) in the Period 3 (Per3) gene have been associated with heritable sleep and circadian variables. The purpose of this study is to investigate the relationship between the VNTR variant of the PER3 gene and genetic predisposition of schizophrenia in a Turkish population. Method: Blood samples were taken from 100 patients with schizophrenia, and from 100 normal controls who are age and sex-matched. PER3 genotyping was performed on DNA by polymerase chain reaction (PCR) using specific primers. Results: For the PER3 VNTR polymorphism, we found no significant differences in the genotype distribution and allele frequency, between the schizophrenia and control groups. No association was noted between clinical and demographical characteristics of schizophrenia patients and the PER3 VNTR genotype distribution. Conclusions: This is the first study investigating association of the PER3 VNTR polymorphism with schizophrenia in a Turkish population. In conclusion, the results of this study do not support an association between the PER3 VNTR polymorphism and risk of schizophrenia in a Turkish population.
dc.identifier.doi10.3103/S0095452721020109
dc.identifier.endpage193en_US
dc.identifier.issn0095-4527
dc.identifier.issn1934-9440
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85104497609
dc.identifier.scopusqualityQ3
dc.identifier.startpage188en_US
dc.identifier.urihttps://doi.org/10.3103/S0095452721020109
dc.identifier.urihttps://hdl.handle.net/11491/7485
dc.identifier.volume55en_US
dc.identifier.wosWOS:000641257000012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherPleiades Publishing Inc
dc.relation.ispartofCytology And Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSchizophreniaen_US
dc.subjectPeriod 3en_US
dc.subjectgeneen_US
dc.subjectpolymorphismen_US
dc.subjectPCRen_US
dc.subjectVNTRen_US
dc.titleThe Impact of PER3 VNTR Polymorphism on the Development of Schizophrenia in a Turkish Population
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu