Separation and elution order of the enantiomers of some beta-agonists using polysaccharide-based chiral columns and normal phase eluents by high-performance liquid chromatography
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Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier B.V.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study separation of enantiomers of 8 chiral ?-agonists were studied on 6 polysaccharide-based chiral columns in polar-organic and alcohol-hydrocarbon mobile phases. No separation of enantiomers was observed on any column with polar-organic mobile phase eluents such as pure methanol, ethanol or acetonitrile. Most of the chiral analytes were resolved into enantiomers when alcohol-hydrocarbon type mobile phases were used. The most successful column was Lux Cellulose-2 on which all 8 chiral analytes were baseline resolved into enantiomers at least with one mobile phase used. The reversal of enantiomer elution order was observed dependent on the chemistry of the chiral selector and the composition of the mobile phase. © 2016 Elsevier B.V.
Açıklama
Anahtar Kelimeler
Beta Agonist, Enantiomer Elution Order, Enantioseparations, HPLC, Mobile-Phase Additives, Polysaccharide-Based Chiral Columns
Kaynak
Journal of Chromatography A
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
1467
Sayı
Künye
Gumustas, M., Ozkan, S. A., & Chankvetadze, B. (2016). Separation and elution order of the enantiomers of some beta-agonists using polysaccharide-based chiral columns and normal phase eluents by high-performance liquid chromatography.
