Voltammetric and RP-LC assay for the antidepressant drug mirtazapine: A validated method for the pharmaceutical dosage form

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dc.contributor.authorAğın, Fatma
dc.contributor.authorKaradaş Bakırhan, Nurgül
dc.contributor.authorUslu, Bengi
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.date.accessioned2019-05-13T09:07:11Z
dc.date.available2019-05-13T09:07:11Z
dc.date.issued2013
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractIn the present paper, rapid, sensitive, selective, accurate and precise analytical methodologies were developed for the determination of the antidepressant drug mirtazapine (MIR) using voltammetry and liquid chromatography. In cyclic voltammetry (CV), MIR showed one sharp oxidation peak and one additional wave in acidic media in the anodic direction; at pH 5.50, the mirtazapine peak was single and sharp. Under optimized conditions, the peak current showed a linear dependence with concentration in the range between 0.212 and 26.54 ?g/ml for glassy carbon (GC) and 1.06 and 26.54 ?g/ml for borondoped diamond (BDD) electrodes using differential pulse (DP) and square wave (SW) voltammetric techniques. The possible oxidation mechanisms are also discussed. A simple and fully validated reverse phase-liquid chromatography (RP-LC) method to test for MIR in tablets was developed using an X-Select RP-18 column (250 × 4.60 mm ID × 5 ?m) at 25 °C with methanol : water (30:70, V/V, containing 15 mM o-phosphoric acid) as the mobile phase adjusted to pH 3.0. The RP-LC method allowed quantification over a MIR concentration range of 1.0-18.0 ?g/ml. MIR was exposed to thermal, photolytic, or oxidative stress, as well as acid and base hydrolysis conditions, and the stressed samples were assayed by the proposed LC method. The proposed methods allow for a number of cost- and time-saving benefits.
dc.identifier.citationAğın, F., Karadaş, N., Uslu, B., Özkan, S. A. (2013). Voltammetric and RP-LC assay for the antidepressant drug mirtazapine: A validated method for the pharmaceutical dosage form. Macedonian Journal of Chemistry and Chemical Engineering, 32(1), 41-55.
dc.identifier.endpage55en_US
dc.identifier.issn1857-5552
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage41en_US
dc.identifier.urihttps://hdl.handle.net/11491/1745
dc.identifier.volume32en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofMacedonian Journal of Chemistry and Chemical Engineering
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDrug Analysisen_US
dc.subjectLiquid Chromatographyen_US
dc.subjectMirtazapineen_US
dc.subjectStability-Indicating Studiesen_US
dc.subjectVoltammetryen_US
dc.titleVoltammetric and RP-LC assay for the antidepressant drug mirtazapine: A validated method for the pharmaceutical dosage form
dc.typeArticle

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