Effects of recurrent sevoflurane anesthesia on cognitive functions with streptozotocin induced Alzheimer disease

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dc.authorscopusid57202302807
dc.authorscopusid14034397500
dc.authorscopusid14627520900
dc.authorscopusid36028383100
dc.authorscopusid36642946400
dc.authorscopusid57192388740
dc.authorscopusid23007939700
dc.contributor.authorErkent, F.D.
dc.contributor.authorIsik, B.
dc.contributor.authorKucuk, A.
dc.contributor.authorOzturk, L.
dc.contributor.authorNeselioglu, S.
dc.contributor.authorDogan, H.T.
dc.contributor.authorArslan, M.
dc.date.accessioned2021-11-01T14:52:00Z
dc.date.available2021-11-01T14:52:00Z
dc.date.issued2019
dc.department[Belirlenecek]
dc.description.abstractOBJECTIVE: We aimed to investigate the effects of recurrent sevoflurane anesthesia on cognitive functions in Alzheimer Disease. MATERIALS AND METHODS: Rats were divided into 4 groups as followed: control (Group C), sevoflurane (Group S), Alzheimer's (Group A) and Alzheimer's + sevoflurane (Group AS)]. Cognitive functions were evaluated with Radial Arm Maze Test (RAMT). Alzheimer model was created by administering 3 mg/kg (10 ?l) STZ. Sevoflurane was administered to S and AS groups. Serum samples and hippocampus tissues were analyzed. RESULTS: In RAM test, the entry-exit data were significantly decreased in A and AS groups. After the 2nd and 3rd administration of anesthesia, the numbers were significantly decreased in Group S. Glial-fibrillaryacidic protein levels were significantly higher in AS compared to the C and S groups. The brain tissue caspase 3 activity was less than 1% in all rats in the Group C, 3 % in 2 rats and 1 % in 1 rat in the Group AS. In A and AS group, serum catalase, myeloperoxidase and ferroxidase activities were found to be higher than in the other groups and myeloperoxidase activity was higher in the AS than in the A Group. Serum native thiol, total thiol and disulfi de levels were found to be significantly different in the A and AS groups. CONCLUSION: Sevoflurane anesthesia negatively affected the cognitive functions (Tab. 5, Fig. 10, Ref. 51). Text in PDF www.elis.sk. © 2019 Comenius University.
dc.identifier.doi10.4149/BLL_2019_149
dc.identifier.endpage893en_US
dc.identifier.issn0006-9248
dc.identifier.issue12en_US
dc.identifier.pmid31855046
dc.identifier.scopus2-s2.0-85076962862
dc.identifier.scopusqualityQ2
dc.identifier.startpage887en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2019_149
dc.identifier.urihttps://hdl.handle.net/11491/6413
dc.identifier.volume120en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherComenius University
dc.relation.ispartofBratislava Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlzheimeren_US
dc.subjectCaspase-3en_US
dc.subjectGFAPen_US
dc.subjectRadial arm maze testen_US
dc.subjectRaten_US
dc.subjectSevofluraneen_US
dc.titleEffects of recurrent sevoflurane anesthesia on cognitive functions with streptozotocin induced Alzheimer disease
dc.typeArticle

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