Protective effect of intravenous lipid emulsion treatment on malathion-induced ovarian toxicity in female rats

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dc.authoridkarsli, mehmet fatih / 0000-0001-8524-2428
dc.authoridNursal, Ayse Feyda / 0000-0001-7639-1122
dc.authoridDelibasi, Ilhan Bahri / 0000-0003-3068-2252
dc.authorwosidkarsli, mehmet fatih / AAD-1574-2019
dc.contributor.authorOzsoy, A. Z.
dc.contributor.authorNursal, A. F.
dc.contributor.authorKarsli, M. F.
dc.contributor.authorUysal, M.
dc.contributor.authorAlici, O.
dc.contributor.authorButun, I.
dc.contributor.authorDelibas, I. B.
dc.date.accessioned2021-11-01T14:58:20Z
dc.date.available2021-11-01T14:58:20Z
dc.date.issued2016
dc.department[Belirlenecek]
dc.description.abstractOBJECTIVE: Malathion (MLT) is an organophosphate (OP) pesticide widely used in agriculture and for domestic purposes for several years. Intravenous lipid emulsion (ILE) has been reported to reduce toxicity caused by some lipid soluble agents. The aim of this study was to investigate the possible protective effects of ILE treatment on acute malathion toxicity in ovarian tissue of female rats. MATERIALS AND METHODS: Twenty-one adult female Wistar rats (weighted 200-250 g) were divided into three groups; control (corn oil, gavage), MLT (one administration of 100 mg/kg/by gavage), 20% ILE (one intravenous administration of 3 ml/kg) plus the MLT group. Blood samples were collected for biochemical tests. The ovaries were removed and fixed for histopathological and immunohistochemical analyses. Malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were investigated in ovarian tissues. Histopathological and immunohistochemical evaluations were performed through scoring ovarian tissue damage and bax/caspase-3 immunoreactivity, respectively. RESULTS: SOD activity decreased in MLT group compared to the control group in tissue samples (p = 0.012). ILE treatment significantly increased SOD activity in MLT+ILE group compared to MLT group in tissue samples (p = 0.017). MLT treatment increased significantly caspase-3 and bax immunoreactivity while ILE decreased bax and caspase-3 immunoreactivity. However, no significant difference was found for MDA levels and GSH-Px activity in both blood and tissue samples and for histopathological results. CONCLUSIONS: The present study revealed that acute oral MLT administration increased oxidative stress and apoptosis in the rats. ILE treatment partially decreased deleterious effects of MLT. Further controlled animal studies are required to define the role of ILE in acute OP poisonings.
dc.identifier.endpage2434en_US
dc.identifier.issn1128-3602
dc.identifier.issue11en_US
dc.identifier.pmid27338071
dc.identifier.startpage2425en_US
dc.identifier.urihttps://hdl.handle.net/11491/6598
dc.identifier.volume20en_US
dc.identifier.wosWOS:000382459700034
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical And Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOrganophosphateen_US
dc.subjectMalathionen_US
dc.subjectIntravenous lipid emulsionen_US
dc.subjectOvaryen_US
dc.titleProtective effect of intravenous lipid emulsion treatment on malathion-induced ovarian toxicity in female rats
dc.typeArticle

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