Endothelin-1 Level in Patients with Simple Renal Cyst

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dc.authorscopusid36704350700
dc.authorscopusid57193887295
dc.authorscopusid57203104298
dc.authorscopusid57216644121
dc.authorscopusid22980250100
dc.authorscopusid55123251500
dc.contributor.authorÇalişkan, S.
dc.contributor.authorSungur, M.
dc.contributor.authorEser, B.
dc.contributor.authorKanbay, M.
dc.contributor.authorKocan, H.
dc.contributor.authorTopaktas, R.
dc.date.accessioned2021-11-01T14:51:42Z
dc.date.available2021-11-01T14:51:42Z
dc.date.issued2019
dc.department[Belirlenecek]
dc.description.abstractINTRODUCTION: Endothelin-1 (ET-1) is potent vasoconstrictive peptide and elevated ET-1 levels are associated with hypertension, endothelial dysfunction and atherosclerosis. Research on (ET-1) has demonstrated that elevated ET-1 levels in autosomal dominant polycystic kidney disease leads to systemic hypertension. The prevalence of simple renal cysts increases with age and the association with simple renal cyst and hypertension is not clear. The aim of this study was to investigate the ET-1 levels in patients with simple renal cyst and compare them with those in healthy adults. MATERIALS AND METHODS: The study included patients that underwent laparoscopic renal cyst decortication in the Department of Urology and healthy controls. Serum and urinary ET-1 levels were measured before surgery and one month after it in the patients with simple renal cyst. Serum ET-1 levels were measured in healthy adult patients. Ambulatory blood pressure was measured in all patients. Glomerular filtration rate was measured according to the chronic kidney disease epidemiology collaboration formula. RESULTS: Thirty-two patients were included in the present study. Of these, 16 patients with simple renal cyst were allocated into group 1 and 16 healthy patients - in group 2. There was no significant difference between systolic and diastolic blood pressure between the groups (. CONCLUSIONS: The present study demonstrated that serum EL-1 level in patients with simple renal cyst was lower than that in healthy people. Further studies are needed to investigate the EL-1 levels in simple renal cyst patients. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.identifier.doi10.3897/folmed.61.e47954
dc.identifier.endpage550en_US
dc.identifier.issn1314-2143
dc.identifier.issue4en_US
dc.identifier.pmid32337867
dc.identifier.scopus2-s2.0-85084169728
dc.identifier.scopusqualityQ3
dc.identifier.startpage545en_US
dc.identifier.urihttps://doi.org/10.3897/folmed.61.e47954
dc.identifier.urihttps://hdl.handle.net/11491/6277
dc.identifier.volume61en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherNLM (Medline)
dc.relation.ispartofFolia medica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBosniaken_US
dc.subjectdecorticationen_US
dc.subjectendothelin-1en_US
dc.subjectlaparoscopyen_US
dc.subjectsimple renal cysten_US
dc.titleEndothelin-1 Level in Patients with Simple Renal Cyst
dc.typeArticle

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