Effect of nicotine exposure during gestation on neonatal rat ovaries

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dc.authorid0000-0002-9668-2063
dc.authorid0000-0002-7869-9662
dc.contributor.authorGörkem, Ümit
dc.contributor.authorToğrul, Cihan
dc.contributor.authorSeçkin, Kerem Doğa
dc.contributor.authorKarslı, Mehmet Fatih
dc.contributor.authorDeveci, Engin
dc.contributor.authorGüngör, Tayfun
dc.date.accessioned2019-05-13T09:07:22Z
dc.date.available2019-05-13T09:07:22Z
dc.date.issued2016
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractThe purpose of present study was to investigate effects of nicotine on follicular development in the neonatal rats. In this study, 14 adult Sprague-Dawley rats weighing 230-260 g (±10 g) were used as experimental animal. After detecting pregnancies with vaginal smear method, pregnant rats were two equal groups were separated. The pregnant females were treated with the nicotine for 21 days and litters were sacrificed at first day of birth. The ovaries of litters were processed through routine paraffin embedding method, serially sectioned by microtome, stained with hematoxylin-Eosin and immunohistochemical technique investigated by light microscope.In the ovary of group treated nicotine, Preventing follicular development was observed in granular degeneration and luteal cells. It was also observed in inflammation and bleeding vessels. Immunohistochemical localization of vimentin was restricted to the granulosa cells and stromal area. Nicotine treatment group in granular cells and luteal cells in E-cadherin expression was weak. We concluded that nicotine might affect the cellular junctions in the ovarian follicular development. The high intensity in the staining with vimentin observed in the granulosa cells of the follicles is probably due to functional changes that occur during the process of cystogenesis. © 2016, E-Century Publishing Corporation. All rights reserved.
dc.identifier.citationGorkem, U., Togrul, C., Seckin, K. D., Karsli, M. F., Deveci, E., & Gungor, T. (2016). Effect of nicotine exposure during gestation on neonatal rat ovaries. Int J Clin Exp Med, 9(2), 4158-4162.
dc.identifier.endpage4162en_US
dc.identifier.issn1940-5901
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage4158en_US
dc.identifier.urihttps://hdl.handle.net/11491/1788
dc.identifier.volume9en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherE-Century Publishing Corporation
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectE-Cadherinen_US
dc.subjectNeonatal Raten_US
dc.subjectNicotineen_US
dc.subjectVEGFen_US
dc.subjectVimentinen_US
dc.titleEffect of nicotine exposure during gestation on neonatal rat ovaries
dc.typeArticle

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