A novel core-shell-based chromatographic method supported by ratio derivative spectrophotometry for the simultaneous determination of perindopril, indapamide, and amlodipine ternary mixtures

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dc.authorid0000-0003-2793-7154
dc.authorid0000-0002-7079-7604
dc.authorid0000-0001-7494-3077
dc.contributor.authorKaradurmuş, Leyla
dc.contributor.authorGümüştaş, Mehmet
dc.contributor.authorKurbanoğlu, Sevinç
dc.contributor.authorUslu, Bengi
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.date.accessioned2019-05-13T09:02:50Z
dc.date.available2019-05-13T09:02:50Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractIn this work, ratio spectra of the frst derivative spectrophotometric and liquid chromatographic methods have been described for the frst time for the simultaneous determination of perindopril (PER), indapamide (IND), and amlodipine (AML) in dosage forms. For chromatographic separations several mobile phase compositions were tested for efcient separation with the use of a new column technology related to superfcially porous particles. Optimum chromatographic separation was achieved using a Kinetex C18 column (150 × 4.6 mm I.D. 5 ?m) at a flow rate of 1.5 mL min-1. The separation was carried out at 30 ° C and the diode array detector was adjusted to 215 nm. As a comparison, a spectrophotometric method depending on the frst derivative of the ratio spectra was developed. The frst derivative of the ratio amplitudes at 227.2 nm for PER, 269.4 nm for AML, 292.0 nm for IND were selected. The proposed methods were successfully applied for the simultaneous assay of the drug combination in pharmaceutical dosage forms and the methods were compared to each other in terms of Student t and F tests for the comparison of their accuracy and precision parameters. © 2018 TUBITAK. All rights reserved.
dc.identifier.citationKaradurmuş, L., Gümüştaş, M., Kurbanoğlu, S., Uslu, B., Özkan, S. A. (2018). A novel core-shell-based chromatographic method supported by ratio derivative spectrophotometry for the simultaneous determination of perindopril, indapamide, and amlodipine ternary mixtures. Turkish Journal of Chemistry, 42(5), 1408-1419.
dc.identifier.doi10.3906/kim-1712-9
dc.identifier.endpage1419en_US
dc.identifier.issn1300-0527
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage1408en_US
dc.identifier.urihttps://doi.org/10.3906/kim-1712-9
dc.identifier.urihttps://hdl.handle.net/11491/1341
dc.identifier.volume42en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTUBİTAK
dc.relation.ispartofTurkish Journal of Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International (CC BY 4.0)*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectAmlodipineen_US
dc.subjectHigh Performance Liquid Chromatographyen_US
dc.subjectIndapamideen_US
dc.subjectPerindoprilen_US
dc.subjectRatio Derivative Spectrophotometryen_US
dc.titleA novel core-shell-based chromatographic method supported by ratio derivative spectrophotometry for the simultaneous determination of perindopril, indapamide, and amlodipine ternary mixtures
dc.typeArticle

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