Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey

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dc.contributor.authorDoğan, Sibel
dc.contributor.authorYalçın, Başak
dc.contributor.authorAtakan, Nilgün
dc.contributor.authorYorulmaz, Ahu
dc.contributor.authorArtüz, Refika Ferda
dc.date.accessioned2019-05-13T09:03:29Z
dc.date.available2019-05-13T09:03:29Z
dc.date.issued2017
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBehçet’s disease (BD) is a severe inflammatory vasculitis which is very common among Turkish population. Recently, IRGM1 (rs13361189), PTGER4 (rs1373692) and CARD8 (rs2043211) polymorphisms are shown to be associated with several inflammatory diseases. In this study, we investigated the association of IRGM1 (rs13361189), PTGER4 (rs1373692) and CARD8 (rs2043211) polymorphisms with BD and their probable implications on clinical manifestations of BD in a Turkish patient cohort. 116 patients and 150 healthy controls genomic DNA were studied. Allele-specific primers were used for genotyping. No significant difference was found between patient and controls according to genotypic distribution and allelic frequencies of IRGM1 (rs13361189), PTGER4 (rs1373692) and CARD8 (rs2043211) (p>0.05). No statistically significant difference was found in genotypic or allellic distribution of the same polymorphisms according to gender or clinical characteristics between patients and controls (p>0.05). Our study is to our knowledge the first report from Turkey regarding BD and IRGM1 (rs13361189), PTGER4 (rs1373692) and CARD8 (rs2043211) polymorphisms. IRGM gene polymorphisms seems to cause predilection for autoimmunity in certain ethnic groups but not in Turkish BD patients. CARD8 gene polymorphisms and other inflammasome related genes may play a role in immune pathomechanisms in BD and separate studies including BD patients with similar clinical characteristics are required for investigating different SNPs as a probable disease susceptibility factor. © 2017 OMU.
dc.identifier.citationDoğan, S., Yalçın, B., Atakan, N., Yorulmaz, A., Artüz, F. (2017). Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey. Journal of Experimental and Clinical Medicine, 34(2), 83-87.
dc.identifier.doi10.5835/jecm.omu.34.02.001
dc.identifier.endpage87en_US
dc.identifier.issn1309-4483
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage83en_US
dc.identifier.urihttps://doi.org/10.5835/jecm.omu.34.02.001
dc.identifier.urihttps://hdl.handle.net/11491/1481
dc.identifier.volume34en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherOndokuz Mayıs Üniversitesi
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBehçet’s Diseaseen_US
dc.subjectCARD8en_US
dc.subjectIRGM1en_US
dc.subjectPTGER4en_US
dc.subjectSNPen_US
dc.titleLack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey
dc.typeArticle

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