Determination of pKa values of some antipsychotic drugs by HPLC-correlations with the kamlet and taft solvatochromic parameters and HPLC analysis in dosage forms

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dc.contributor.authorŞanlı, Senem
dc.contributor.authorAkmeşe, Bediha
dc.contributor.authorAltun, Yüksel
dc.date.accessioned2019-05-13T08:59:00Z
dc.date.available2019-05-13T08:59:00Z
dc.date.issued2013
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractIn this study, ionization constant (pKa) values were determined by using the dependence of the retention factor on the pH of the mobile phase for four ionizable drugs, namely, risperidone (RI), clozapine (CL), olanzapine (OL), and sertindole (SE). The effect of the mobile phase composition on the pKa was studied by measuring the pKa at different acetonitrile-water mixtures in an HPLC-UV method. To explain the variation of the pKa values obtained over the whole composition range studied, the quasi-lattice quasi-chemical theory of preferential solvation was applied. The pKa values of drugs were correlated with the Kamlet and Taft solvatochromic parameters. Kamlet and Taft's general equation was reduced to two terms by using combined factor analysis and target factor analysis in these mixtures: the independent term and the hydrogenbond donating ability ?. The HPLC-UV method was successfully applied for the determination of RI, OL, and SE in pharmaceutical dosage forms. CL was chosen as an internal standard. Additionally, the repeatability, reproducibility, selectivity, precision, and accuracy of the method in all media were investigated and calculated.
dc.identifier.citationŞanlı, S., Akmeşe, B., Altun, Y. (2013). Determination of pKa values of some antipsychotic drugs by HPLC-correlations with the kamlet and taft solvatochromic parameters and HPLC analysis in dosage forms. Journal of AOAC International, 96(1), 60-66.
dc.identifier.doi10.5740/jaoacint.11-494
dc.identifier.endpage66en_US
dc.identifier.issn1060-3271
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage60en_US
dc.identifier.urihttps://doi.org/10.5740/jaoacint.11-494
dc.identifier.urihttps://hdl.handle.net/11491/1235
dc.identifier.volume96en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofJournal of AOAC International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject[Belirlenecek]en_US
dc.titleDetermination of pKa values of some antipsychotic drugs by HPLC-correlations with the kamlet and taft solvatochromic parameters and HPLC analysis in dosage forms
dc.typeArticle

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