Protective effect of caffeic acid phenethyl ester (CAPE) on ischemia-reperfusion injury in rat ovary

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dc.contributor.authorGörkem, Ümit
dc.contributor.authorToğrul, Cihan
dc.contributor.authorŞahin, İzzet
dc.contributor.authorCoşkun, Buğra
dc.contributor.authorÖzat, Mustafa
dc.contributor.authorGüngör, Tayfun
dc.contributor.authorDeveci, Engin
dc.date.accessioned2019-05-13T08:57:37Z
dc.date.available2019-05-13T08:57:37Z
dc.date.issued2017
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractThe aim of this study was to investigate the effects of caffeic acid phenethyl ester (CAPE) as a prophylactic agent on ischemia/reperfusion (I/R) injury in the rat ovary. A total of 28 Wistar rats were divided into 4 equal groups: (I) sham, (II) ischemia, (III) ischemia + reperfusion, and (IV) IR + CAPE. In groups I and II, ovary torsion was not performed and no drug was administered. In group III, 1 hour of ischemia and 2 hours of reperfusion were performed and no drug was given. Ovarian tissue concentrations of malondialdehyde were significantly higher in the torsion and detorsion groups compared with the sham and Cape groups (P<0.005). The detorsion group showed preantral ovarian follicles and luteal folicules around the blood vessels and positive expression of CD34. In the CAPE group the stromal vascular endothelium with weak expression of CD34 was detected in small areas, and the ovarian follicles and the corpus luteum showed negative expression of CD34. In the study, Biochemical and histopathological results of CAPE treatment was considered to torsion-detorsioned the model showed a protective effect against tissue damage. © 2017, Universidad de la Frontera. All rights reserved.
dc.identifier.citationGörkem, Ü., Toğrul, C., Şahin, İ., Coşkun, B., Özat, M., Güngör, T., Deveci, E. (2017). Protective effect of caffeic acid phenethyl ester (CAPE) on ischemia-reperfusion injury in rat ovary. International Journal of Morphology, 35(1), 141-147.
dc.identifier.doi10.4067/S0717-95022017000100023
dc.identifier.endpage147en_US
dc.identifier.issn0717-9367
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage141en_US
dc.identifier.urihttps://doi.org/10.4067/S0717-95022017000100023
dc.identifier.urihttps://hdl.handle.net/11491/969
dc.identifier.volume35en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniversidad de la Frontera
dc.relation.ispartofInternational Journal of Morphology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCaffeic Acid Phenethyl Esteren_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectOvaryen_US
dc.subjectRaten_US
dc.titleProtective effect of caffeic acid phenethyl ester (CAPE) on ischemia-reperfusion injury in rat ovary
dc.title.alternativeEfecto protector de ester feniletílico de acido cafeico (CAPE) en la lesión por isquemia-reperfusión en ovario de rataen_US
dc.typeArticle

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