Magnetic Nanosensor Design and Assay of an Anti-Tuberculosis Drug

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dc.authoridimanzadeh, hamideh / 0000-0002-1055-3122
dc.authoridKARADAS BAKIRHAN, NURGUL / 0000-0001-5469-9142
dc.contributor.authorImanzadeh, Hamideh
dc.contributor.authorBakirhan, Nurgul K.
dc.contributor.authorHabibi, Biuck
dc.contributor.authorOzkan, Sibel A.
dc.date.accessioned2021-11-01T15:02:04Z
dc.date.available2021-11-01T15:02:04Z
dc.date.issued2019
dc.department[Belirlenecek]
dc.description.abstractIn the present work, an anti-tuberculosis drug, morphazinamide HCl (MRA) was investigated at ultra-trace level in real sample for the first time. Iron (III) oxide nanoparticles (Fe(2)O(3)NPs) were casted on a glassy carbon electrode (GCE) for the determination of MRA. Cyclic voltammetry, electrochemical impedance spectroscopy, transmission electron microscopy, scanning electron microscopy and energy-dispersive X-ray spectroscopy were employed for morphological characterization of the electrode surface. The results displayed a higher surface area and greater conductivity for the Fe(2)O(3)NPs modified glassy carbon electrode (Fe(2)O(3)NPs/ GCE) than bare GCE. The square wave voltammetry response of the Fe(2)O(3)NPs/GCE was linear with MRA concentration in the range of 1 mu M to 100 mu M under optimized conditions (0.1M phosphate buffer solution at pH 3.0; drop-casting volume 10 mu L; accumulation time 15 s; accumulation potential -0.3 V), with a detection limit of 0.21 nM. Also, the proposed procedure was very efficient for MRA determination from human serum sample with high recoveries. (C) 2019 The Electrochemical Society.
dc.identifier.doi10.1149/2.0591912jes
dc.identifier.endpageB941en_US
dc.identifier.issn0013-4651
dc.identifier.issn1945-7111
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85073418333
dc.identifier.scopusqualityQ1
dc.identifier.startpageB933en_US
dc.identifier.urihttps://doi.org/10.1149/2.0591912jes
dc.identifier.urihttps://hdl.handle.net/11491/6832
dc.identifier.volume166en_US
dc.identifier.wosWOS:000475504900004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherElectrochemical Soc Inc
dc.relation.ispartofJournal Of The Electrochemical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject[No Keywords]en_US
dc.titleMagnetic Nanosensor Design and Assay of an Anti-Tuberculosis Drug
dc.typeArticle

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