Antiproliferative properties and structural analysis of newly synthesized Schiff bases bearing pyrazole derivatives and molecular docking studies

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dc.authoridBaloglu, Mehmet Cengiz / 0000-0003-2976-7224
dc.authorwosidBaloglu, Mehmet Cengiz / P-7411-2016
dc.contributor.authorSener, Nesrin
dc.contributor.authorozkinali, Sevil
dc.contributor.authorAltunoglu, Yasemin Celik
dc.contributor.authorYerlikaya, Serife
dc.contributor.authorGokce, Halil
dc.contributor.authorZurnaci, Merve
dc.contributor.authorSener, Izzet
dc.date.accessioned2021-11-01T15:05:56Z
dc.date.available2021-11-01T15:05:56Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractNew pyrazole Schiffbases containing azo groups were synthesized using the condensation reaction between p-nitrobenzaldehyde and (E)-4-(phenyl)-1-H-pyrazole-3,5-diamine in the molar ratio of 1:2. Characterization of the compounds was performed by spectroscopic techniques, including IR, UV-Vis, H-1-NMR and C-13-NMR. Biological activity of the compounds was evaluated by analyzing DNA protection, antimicrobial and anticancer properties. Compound 4 was effective for Salmonella typhimurium with the MIC concentration of 62.5 mu g/mL. Moreover, this compound had the highest protection activity on DNA. Cytotoxic activity of compound 4 was determined on the HeLa cancer cell line with the IC50 concentration of 976.6 mu M. The anti-cancer characteristic of compounds 4 and 5 for HeLa cancer was theoretically analyzed by molecular docking study as well. Among the tested compounds, compound 4 possessed significant results due to its in vitro cytotoxic properties. Therefore, it may be considered as a potential bioactive agent for cancer treatment studies. In addition, further in vivo analysis can be performed to indicate its anticancer property. (C) 2021 Elsevier B.V. All rights reserved.
dc.description.sponsorshipScientific Research Projects Council of Kastamonu University [KuBAP01/201817]en_US
dc.description.sponsorshipThe authors are grateful to the Scientific Research Projects Council of Kastamonu University (KuBAP01/201817) .en_US
dc.identifier.doi10.1016/j.molstruc.2021.130520
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85106596873
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2021.130520
dc.identifier.urihttps://hdl.handle.net/11491/7447
dc.identifier.volume1241en_US
dc.identifier.wosWOS:000664754100008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal Of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPyrazoleen_US
dc.subjectAzo-Imineen_US
dc.subjectSchiffbasesen_US
dc.subjectDNA protectionen_US
dc.subjectCytotoxic activityen_US
dc.subjectAntimicrobial activityen_US
dc.subjectMolecular dockingen_US
dc.titleAntiproliferative properties and structural analysis of newly synthesized Schiff bases bearing pyrazole derivatives and molecular docking studies
dc.typeArticle

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