Synthesis of bis(thiosemicarbazone) derivatives: Definition, crystal structure, biological potential and computational analysis
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Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor and Francis Ltd.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
(2-(2-(2-methoxyphenyl)hydrazono)cyclohexane-1,3-diylidene) bis(hydrazine carbothioamide) (L1), 4-(2-(-2,-6-bis(2-carbamothioylhydrazono) cyclohexylidene) hydrazinyl)benzoic acid (L2), and (2-(2-(4-bromophenyl) hydrazono) cyclohexane-1,3-diylidene) bis(hydrazinecarbothioamide) (L3) bis(thiosemicarbazone) derivative compounds were synthesized by the condensation reaction of thiosemicarbazide and various ketone compounds. The structures of synthesized compounds were characterized by using FT-IR, 1H and 13C-NMR spectra, elemental analysis and mass spectra. Also, the structure of L1 has been determined by X-ray crystallographic analysis. Additionally, the antioxidant activities (free radical (DPPH) scavenging, iron chelating and reducing power) of compounds were evaluated. Especially, L3 displayed good DPPH activity (84.13%) at 100 mg/L. Moreover, pBR322 plasmid DNA cleavage activity was examined and all of the compounds were able to cleave the plasmid DNA. Finally, the ground state geometries of the thiosemicarbazone derivatives were optimized using Density Functional Theory applications at B3LYP/6-31G (d,p) level in order to obtain information about the 3D geometries and electronic structure, © 2018 Taylor & Francis Group, LLC.
Açıklama
Anahtar Kelimeler
Antioxidant, Computational Analysis, Crystal Structure, DNA Cleavage, Thiosemicarbazone
Kaynak
Phosphorus, Sulfur and Silicon and the Related Elements
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
193
Sayı
1
Künye
Ateş, D., Gülcan, M., Gümüş, S., Şekerci, M., Özdemir, S., Şahin, E., Çolak, N. (2018). Synthesis of bis (thiosemicarbazone) derivatives: Definition, crystal structure, biological potential and computational analysis. Phosphorus, Sulfur, and Silicon and the Related Elements, 193(1), 14-22.
