Synthesis and Characterization of Some New 1,3,4-Thiadiazole Compounds Derived from 3,4-(Methylenedioxy)Cinnamic Acid and their Antimicrobial Activities

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dc.authoridOzkinali, Asosc. Prof. Dr. Sevil / 0000-0001-9166-191X
dc.authoridgur, mahmut / 0000-0001-9942-6324
dc.authorwosidOzkinali, Asosc. Prof. Dr. Sevil / AAG-6865-2019
dc.authorwosidsener, izzet / AAD-8297-2020
dc.contributor.authorMuglu, Halit
dc.contributor.authorGur, Mahmut
dc.contributor.authorBen Hsin, Maesm Ahmed Mohamed
dc.contributor.authorSener, Nesrin
dc.contributor.authorOzkinali, Sevil
dc.contributor.authorOzkan, Osman Emre
dc.contributor.authorSener, Izzet
dc.date.accessioned2021-11-01T15:02:03Z
dc.date.available2021-11-01T15:02:03Z
dc.date.issued2019
dc.department[Belirlenecek]
dc.description.abstractSome new 1,3,4-thiadiazole compounds derived from 3,4-(methylenedioxy)cinnamic acid were synthesized in this study. Their structures were determined using UV-Vis, IR, H-1-NMR, and C-13-NMR spectroscopy. Moreover, the antibacterial activities of the new 1,3,4-thiadiazole derivatives were tested against Gram positive (Enterococcus durans, Bacillus subtilis, and Staphylococcus aureus) and gram negative (Salmonella typhimurium, Escherichia coli, Salmonella enteritidis, Salmonella infantis, Salmonella kentucky, Enterobacter aerogenes) bacteria using the disk diffusion method. Furthermore, their antifungal activity was tested against Candida albicans using the disk diffusion method. Some of the synthesized compounds (V, VII, XIII, and XIV) showed antibacterial activity against S. aureus. Also, one synthesized compound (VIII) showed antibacterial activity against E. coli, exhibiting 8 and 9 mm inhibition zones using 50 and 80 mu L. One compound (IX) showed antibacterial activity against E. aerogenes, exhibiting a 12 mm inhibition zone using 80 mu L. One compound (XIII) showed antibacterial activity against S. kentucky, exhibiting an inhibition zone of about 9 mm using 80 mu L. Also, one compound (VII) showed antibacterial activity against E. durans, exhibiting 7, 7, and 8 mm inhibition zones using 30, 50, and 80 mu L. None of the compounds (I-XV) showed antifungal activity against C. albicans. These results showed that some of the synthesized compounds could be used as antibacterial agents.
dc.identifier.doi10.2174/1570178616666190118153815
dc.identifier.endpage836en_US
dc.identifier.issn1570-1786
dc.identifier.issn1875-6255
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85074061151
dc.identifier.scopusqualityQ4
dc.identifier.startpage825en_US
dc.identifier.urihttps://doi.org/10.2174/1570178616666190118153815
dc.identifier.urihttps://hdl.handle.net/11491/6822
dc.identifier.volume16en_US
dc.identifier.wosWOS:000483301600006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofLetters In Organic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject1,3,4-Thiadiazoleen_US
dc.subjectantimicrobial activityen_US
dc.subjectIR and NMR spectroscopyen_US
dc.subjectantibacterial activitiesen_US
dc.subjectgram positiveen_US
dc.subjectgram-negative bacteriaen_US
dc.titleSynthesis and Characterization of Some New 1,3,4-Thiadiazole Compounds Derived from 3,4-(Methylenedioxy)Cinnamic Acid and their Antimicrobial Activities
dc.typeArticle

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