Spectroscopic, antiproliferative and antiradical properties of Cu(II), Ni(II), and Zn(II) complexes with amino acid based Schiff bases

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dc.contributor.authorKaragöz Genç, Zuhal
dc.contributor.authorSelçuk, Sibel
dc.contributor.authorSandal, Süleyman
dc.contributor.authorÇolak, Naki
dc.contributor.authorKeser, Serhat
dc.contributor.authorSekerci, Memet
dc.contributor.authorKaratepe, Mustafa
dc.date.accessioned2019-05-13T08:58:55Z
dc.date.available2019-05-13T08:58:55Z
dc.date.issued2014
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractNovel six Cu(II), Ni(II), and Zn(II) complexes with Schiff bases derived from 4-aminobenzoic acid with terephtaldehyde and amino acids (glycine, ?-alanine). Structures have been proposed from elemental analysis, UV-Vis, IR, NMR, TGA, DTA, and magnetic measurements. Spectroscopic studies suggest that coordination occurs through azomethine nitrogen, hydroxyl group, and carbonyl oxygen of the ligands to the metal ions. The elemental analyses of the complexes where L is Schiff base ligands, are confined to the stoichiometry of the type M2L2(CH3COO)2 [M = Cu(II)]; and M2L(CH3COO)2[M = Ni(II) and Zn(II)]. The cytotoxicity activities of the compounds against human breast carcinoma MCF-7 cell line have been studied. Ligands and their Zn(II) compounds inhibited cell proliferation of MCF-7 cancer cell lines in a dose- and time-dependent manner. The free radical scavenging activity was measured by 1,1-diphenyl-2-picryl- hydrazil. Our results show that the synthesized compounds induced oxidative damage by increasing the lipid peroxidation in yeast since MDA formation was increased, and it could be concluded that the synthesized compounds caused oxidative stress. In addition, the antioxidant activities of the synthesized compounds were very much lower than those of standard antioxidants. © Springer Science+Business Media 2013.
dc.identifier.citationGenç, Z. K., Selçuk, S., Sandal, S., Çolak, N., Keser, S., Şekerci, M., Karatepe, M. (2014). Spectroscopic, antiproliferative and antiradical properties of Cu (II), Ni (II), and Zn (II) complexes with amino acid based Schiff bases. Medicinal Chemistry Research, 23(5), 2476-2485.
dc.identifier.doi10.1007/s00044-013-0826-7
dc.identifier.endpage2485en_US
dc.identifier.issn1054-2523
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage2476en_US
dc.identifier.urihttps://doi.org/10.1007/s00044-013-0826-7
dc.identifier.urihttps://hdl.handle.net/11491/1222
dc.identifier.volume23en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBirkhauser Boston
dc.relation.ispartofMedicinal Chemistry Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntiproliferative Activityen_US
dc.subjectDPPHen_US
dc.subjectSchiff Baseen_US
dc.subjectSpectroscopyen_US
dc.titleSpectroscopic, antiproliferative and antiradical properties of Cu(II), Ni(II), and Zn(II) complexes with amino acid based Schiff bases
dc.typeArticle

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