Electroanalytical characteristics of antipsychotic drug ziprasidone and its determination in pharmaceuticals and serum samples on solid electrodes

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dc.contributor.authorKul, Dilek
dc.contributor.authorGümüştaş, Mehmet
dc.contributor.authorUslu, Bengi
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.date.accessioned2019-05-10T09:39:18Z
dc.date.available2019-05-10T09:39:18Z
dc.date.issued2010
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractZiprasidone is a psychotropic agent used for the treatment of schizophrenia. Its oxidation was investigated electrochemically at boron-doped diamond and glassy carbon electrodes using cyclic, differential pulse, and square wave voltammetry. The dependence of the peak current and peak potentials on pH, concentration, nature of the buffer, and scan rate were examined. The process was diffusion and adsorption controlled for boron-doped diamond and glassy carbon electrodes, respectively. The possible mechanism of oxidation was discussed with some model compounds that have indole and piperazine oxidations. A linear response was obtained between 8 × 10-7 and 8 × 10-5 M for the first peak in acetate buffer (pH 5.5) and between 2 × 10-6 and 2 × 10-4 M for the second peak in 0.1 M H2SO4 with boron-doped diamond electrode for differential pulse and square wave voltammetric techniques. The reproducibility and accuracy of the proposed methods were found between 0.31 and 1.20, 99.27 and 100.22, respectively. The recovery studies were also achieved to check selectivity and accuracy of the methods. The proposed methods were applied for the determination of ziprasidone from pharmaceutical dosage forms and human serum samples without any time-consuming extraction, separation, evaporation or adsorption steps prior to drug assay except precipitation of the proteins using acetonitrile. The results were statistically compared with those obtained through an established LC-UV technique, no significant differences were been found between the voltammetric and LC methods. © 2010 Elsevier B.V. All rights reserved.
dc.identifier.citationKul, D., Gumustas, M., Uslu, B., & Ozkan, S. A. (2010). Electroanalytical characteristics of antipsychotic drug ziprasidone and its determination in pharmaceuticals and serum samples on solid electrodes. Talanta, 82(1), 286-295.
dc.identifier.doi10.1016/j.talanta.2010.04.036
dc.identifier.endpage295en_US
dc.identifier.issn0039-9140
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage286en_US
dc.identifier.urihttps://doi.org/10.1016/j.talanta.2010.04.036
dc.identifier.urihttps://hdl.handle.net/11491/662
dc.identifier.volume82en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofTalanta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBoron-Doped Diamond Electrodeen_US
dc.subjectGlassy Carbon Electrodeen_US
dc.subjectPharmaceuticalsen_US
dc.subjectVoltammetryen_US
dc.subjectZiprasidoneen_US
dc.titleElectroanalytical characteristics of antipsychotic drug ziprasidone and its determination in pharmaceuticals and serum samples on solid electrodes
dc.typeArticle

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