Effect of precipitation inhibitors on supersaturation and solubility of furosemide

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dc.authoridOzturk, Naile / 0000-0002-7617-8433
dc.authorwosidOzturk, Naile / F-3650-2017
dc.contributor.authorGulsun, Tugba
dc.contributor.authorOzturk, Naile
dc.contributor.authorKara, Asli
dc.contributor.authorSahin, Selma
dc.contributor.authorVural, Imran
dc.date.accessioned2021-11-01T15:05:51Z
dc.date.available2021-11-01T15:05:51Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractFurosemide is a widely used diuretic drug for the treatment of edema associated with heart, liver cirrhosis, renal diseases and hypertension. It is a Class IV drug with low aqueous solubility and low permeability according to Biopharmaceutics Classification System (BCS). Furosemide was chosen as a model drug to examine the effect of polymeric precipitation inhibitors (PPIs) on the supersaturation and solubility. Solubility and concentration change of furosemide as a function of time at pH 1.2 and 6.8 were determined to show the effects of PPIs on furosemide solubility. The 24 h equilibrium solubility of furosemide was 0.017 +/- 0.004 and 3.62 +/- 0.201 mg/mL at pH 1.2 and pH 6.8 buffer solutions, respectively. PPI type and concentration (0.05%, 0.25%) did not increase furosemide solubility at pH 1.2. However, both hydroxypropylmethylcellulose (HPMC) and polyvinylpyrrolidoneK17 (PVPK17) at two concentrations increased furosemide solubility at pH 1.2 and 6.8. In addition, viscosity of solutions was in the range of 2.2-3.7 centipoise, and it was not influenced by PPIs concentrations. Our results showed that designing supersaturated formulations using PPIs can be useful and promising to enhance solubility of furosemide.
dc.identifier.doi10.29228/jrp.11
dc.identifier.endpage217en_US
dc.identifier.issn2630-6344
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85103506237
dc.identifier.scopusqualityQ3
dc.identifier.startpage209en_US
dc.identifier.urihttps://doi.org/10.29228/jrp.11
dc.identifier.urihttps://hdl.handle.net/11491/7424
dc.identifier.volume25en_US
dc.identifier.wosWOS:000629451200011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherMarmara Univ
dc.relation.ispartofJournal Of Research In Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFurosemideen_US
dc.subjectprecipitation inhibitorsen_US
dc.subjectsolubilityen_US
dc.subjectsupersaturationen_US
dc.titleEffect of precipitation inhibitors on supersaturation and solubility of furosemide
dc.typeArticle

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