N-O tethered carbenoid cyclopropanation facilitates the synthesis of a functionalized cyclopropyl-fused pyrrolidine

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dc.authorid0000-0003-0759-1299
dc.contributor.authorKalia, Dimpy
dc.contributor.authorMerey, Gökçe
dc.contributor.authorGuo, Min
dc.contributor.authorSintim H.O.
dc.date.accessioned2019-05-10T09:39:02Z
dc.date.available2019-05-10T09:39:02Z
dc.date.issued2013
dc.departmentHitit Üniversitesi, Mühendislik Fakültesi, Kimya Mühendisliği Bölümü
dc.description.abstractWe report a facile approach to a cyclopropyl-fused pyrrolidine, which contains four stereogenic centers, by employing the N-O tethered carbenoid methodology. The synthesis was facilitated by the development of a direct Mitsunobu reaction of alcohols with N-alkyl-N-hydroxyl amides to give diazo precursors, which upon intramolecular cyclopropanation yielded a library of N-O containing cyclopropyl-fused bicyclic intermediates. Elaboration of the N-O moiety of one member of this library resulted in the formation of the desired pyrrolidine ring demonstrating the potential of this methodology for making cyclopropyl-fused heterocycles. © 2013 American Chemical Society.
dc.identifier.citationKalia, D., Merey, G., Guo, M., & Sintim, H. O. (2013). N–O Tethered Carbenoid Cyclopropanation Facilitates the Synthesis of a Functionalized Cyclopropyl-Fused Pyrrolidine. The Journal of organic chemistry, 78(12), 6131-6142.
dc.identifier.doi10.1021/jo400788a
dc.identifier.endpage6142en_US
dc.identifier.issn0022-3263
dc.identifier.issue12en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage6131en_US
dc.identifier.urihttps://doi.org/10.1021/jo400788a
dc.identifier.urihttps://hdl.handle.net/11491/589
dc.identifier.volume78en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofJournal of Organic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject[Belirlenecek]en_US
dc.titleN-O tethered carbenoid cyclopropanation facilitates the synthesis of a functionalized cyclopropyl-fused pyrrolidine
dc.typeArticle

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