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Öğe A Comparison Of Manual Hemocytometry And Different Modes Of Mindray BC-6800 Hematology Analyzer For Cell Count In Peritoneal And Pleural Fluids(2020) Savcı, Ünsal; Şahin, Mustafa Fethi; Eser, Barış; Kayadibi, HüseyinObjective: Total white blood cell (WBC) count in body fluids (BF) is important in diagnosis and treatment of inflammatory and infectious diseases. We aimed to compare hemogram and BF modes of Mindray BC-6800 hematology analyzer with the manual hemocytometry method for determination of total WBC count in peritoneal and pleural fluids. Method: Our study consisted of a total of 143 specimens, 109 peritoneal fluid and 34 pleural effusion fluid. Each sample was analyzed consecutively twice, first with the manual method and, later with both hemogram mode and the BF mode of Mindray BC-6800 automated hematology analyzer. Results: There was a statistically significant difference between manual count and hemogram mode (for peritoneal fluids p< 0.001, for pleural fluids p< 0.001). There was a statistically significant difference between the hemogram mode and BF mode too. (for peritoneal fluids p< 0.001, for pleural fluids p< 0.001). However, there was no statistically significant difference between the manual count and BF mode (for peritoneal fluids p=0.236, for pleural fluids p=0.627). Less than100 cells/mL, there was a statistically significant difference between each of the counting methods (Manual count vs hemogram mode p< 0.001, manual count vs BF mode p= 0.012, hemogram mode vs BF mode p< 0.001).More than 100 cells/mL, there was no statistically significant difference between manual count and the BF mode (p= 0.332). However, there were statistically significant differences between manual count and hemogram mode, and hemogram mode and BF mode (p= 0.003 and p< 0.001 respectively). Conclusion: The use of manual method instead of hematology analyzer is more convenient in samples <100 cells/mL, and BF mode may be used as a screening tool in samples >100 cells/mL.Öğe A membranous nephropathy case: Is it related to sulfasalazine?(Elsevier Espana S.L., 2016) Bağdatoğlu, Oktay; Maraş, Yüksel; Yayar, Özlem; Eser, BarışIn adult age group, the cause of membranous glomerulonephritis (MG) cannot be detected in about 75% of the patients. These cases are defined as idiopathic (primary) MG. MG associated with drugs and other diseases are defined as secondary MG. Penicillamine and gold salts, formerly used in the treatment of rheumatoid arthritis (RA), are responsible for the development of MG. Amyloidosis, analgesic nephropathy, glomerulonephritis and rheumatoid vasculitis can be observed in RA.Öğe Comparison of aortic pressures and aortic elastic properties between patients with end-stage renal disease and healthy controls(Akademiai Kiado Zrt, 2019) Kalçık, Macit; Yetim, Mücahit; Doğan, Tolga; Doğan, İbrahim; Eser, Barış; Bekar, Lütfü; Karavelioğlu, YusufBackground: Current evidence indicates that vascular calcification plays an essential role in the development of cardiovascular diseases in end-stage renal disease (ESRD) patients. Arterial stiffness is a marker of increased cardiovascular risk in various populations. The aim of this study is to evaluate the elastic properties of ascending aorta in patients with ESRD. Methods: This single-center study enrolled 96 patients (45 females, age: 57.2 +/- 12.8 years) with ESRD and 96 healthy controls (52 females, age: 55.3 +/- 10.1 years). Aortic pressures and aortic elastic parameters including aortic strain, aortic distensibility, aortic stiffness index, and aortic compliance were calculated using accepted formulae. Results: The hemodynamic parameters including aortic pulse pressure, aortic mean pressure, aortic fractional pulse pressure, and aortic pulsatility index were significantly higher in patients with ESRD. Systolic and diastolic aortic diameters were similar between the groups. However, pulsatile aortic diameter change, aortic strain, aortic distensibility, and aortic compliance were significantly lower, whereas aortic stiffness index was significantly higher in ESRD group. Conclusions: The results demonstrated that a significant difference was present in terms of aortic blood pressures between patients with ESRD and controls. In addition, the elastic properties of ascending aorta were decreased in patients with ESRD.Öğe Echocardiographic predictors of interatrial block in patients with severe chronic kidney disease(Springer, 2020) Kalçık, Macit; Yetim, Mücahit; Doğan, Tolga; Eser, Barış; Doğan, İbrahim; Bekar, Lütfü; Karavelioğlu, YusufBackground Interatrial block (IAB), defined as a conduction delay between the right and left atrium, is manifested on the electrocardiogram as a prolonged P-wave duration. Large number of studies recently have been published regarding the prevalence of IAB and its associations with the risk of atrial fibrillation and ischemic stroke. Cardiovascular diseases are the leading causes of mortality in chronic kidney disease (CKD). In this study, we aimed to investigate echocardiographic predictors of IAB in patients with severe CKD. Methods This study enrolled a total of 155 patients [male: 95 (61.3%), mean age: 56.3 +/- 12.8 years] with severe CKD (glomerular filtration rate < 30 mL/min). All patients were evaluated by electrocardiography and transthoracic echocardiography. IAB was defined as P wave duration of >= 120 ms on electrocardiography. Results Electrocardiography revealed IAB in 54 patients. The baseline demographic characteristics of the patients were similar in both groups with and without IAB. Left atrial diameter (LAD), left ventricular end-systolic and end-diastolic diameters, interventricular septal thickness, posterior wall thickness, left ventricular mass, left ventricular mass index (LVMI), and the prevalence of left ventricular hypertrophy were found to be significantly increased in patients with IAB. Increased LAD (OR = 1.119; 95% CI 1.019-1.228; p = 0.019) and LVMI (OR = 1.036; 95% CI 1.003-1.070; p = 0.031) were found to be independent predictors of IAB. Conclusion A significant association exists between the presence of IAB and echocardiographic parameters related to left ventricular hypertrophy and left atrial dilatation. Presence of IAB may be an additional and easy diagnostic marker for risk stratification of patients with severe CKD.Öğe FGF-23, Inflammation and Iron Metabolism in the Early Stages of Autosomal Dominant Polycystic Kidney Disease(2020) Doğan, İbrahim; Ocak, Birol; Eser, Barış; Kayadibi, Hüseyin; Özkurt, Sultan; Kısakol, GürcanTo investigate the correlation of Fibroblast Growth Faktör-23 (sFGF-23) with iron status, inflammation and carotid intima-media thickness (CIMT) in the early stages of autosomal dominant polycystic kidney disease (ADPKD). Forty ADPKD patients (24 female) with normal creatinine levels and 40 healthy volunteers (21 female) were included in the study. Serum FGF-23 levels were measured using the ELISA technique. The associations between sFGF-23 with CIMT, hs-CRP, neutrophil lymphocyte ratio (NLR) and iron parameters were evaluated using correlation analysis. Patients’ sFGF-23 levels were significantly higher [245 (182-963) pg/mL; vs. 219.6 (34-494) pg/mL], (P< 0.001). NLR and hs-CRP were also found to be statistically higher in patients than controls (P< 0.001 and P= 0.003, respectively). CIMT was significantly higher in the patient group (P= 0.037). There were statistically significant negative correlations between sFGF-23 and calcium, hemoglobin, hematocrit, serum iron, ferritin, and NLR (P= 0.009, P= 0.035, P= 0.002, P= 0.033, P= 0.017, P= 0.023, respectively), and positive correlations with phosporus, total iron binding capacity and sFGF-23 (P= 0.010, P= 0.049, respectively). There was no statistically significant correlation between sFGF23 and PTH, hs-CRP and CIMT. In multivariate lineer regression analysis, serum phosphorus level was statistically significiant independent risk factor for the determinantion of sFGF-23 level [B: 0.318, OR:130,662(32,715-228,610), P=0.010]. Our study results support an inverse relationship between sFGF-23 and iron deficiency but no relationship between sFGF-23 and inflammation and atherosclerosis in the early stages of ADPKD.Öğe Fibroblast growth factor is associated to left ventricular mass index, anemia and low values of transferrin saturation(Elsevier Espana S.L., 2015) Eser, Barış; Yayar, Özlem; Büyükbakkal, Mehmet; Erdoğan, Bülent; Ercan, Zafer; Merhametsiz, Özgür; Haspulat, Ayhan; Gök Oğuz, Ebru; Doğan, İbrahim; Canbakan, Başol; Aylı, M. DenizBackground: Fibroblast growth factor 23 (FGF-23) is a phosphorus-regulating hormone. In chronic kidney disease (CKD), circulating FGF-23 levels are markedly elevated and independently associated with mortality. Left ventricular hypertrophy (LVH) is a potent risk factor for mortality in CKD, and FGFs have been implicated in the pathogenesis of myocardial hypertrophy. In addition, the effect of anemia on CV disease and LVH is well known in CKD. A relation between iron and FGF-23 metabolism is mentioned in a few studies. The aim of this study was to test the association of FGF-23 levels with echocardiographic (ECHO) and iron parameters in peritoneal dialysis patients (PD). Methods: In this cross-sectional study, 61 subjects with PD (29 women and 32 men, mean age: 46.9 ± 13.3 years, mean PD vintage: 69.5 ± 39 months) underwent echocardiograms to assess left ventricular mass index (LVMI). Medical treatments and average values of the basic laboratory results of the last 6 months for all patients were recorded. Serum FGF-23 concentrations were measured using intact FGF-23 (iFGF-23) human enzyme-linked immunosorbent assay (ELISA) kit. According to the median levels of serum FGF-23 the patients were grouped into two (FGF-23 high and low groups). Results: Significant positive correlation was recorded between serum FGF-23 levels and LVMI (P= 0.023). There was also significant difference in terms of hemoglobin (12.1 ± 2 versus 11.0 ± 2, P= 0.017), transferrin saturation (TSAT) (24.9 ± 16.8 versus 19.5 ± 10.8, P= 0.042) between low and high FGF-23 group. Also in linear regression analysis the negative relation between FGF-23 and hemoglobin is persisted (r= 0.199, P= 0.045). Conclusions: FGF-23 is associated with LVMI, anemia and low TSAT in patients with PD. Whether increased FGF-23 is a marker or a potential mechanism of myocardial hypertrophy and anemia in patients with end-stage renal disease (ESRD) requires further study. © 2015 Sociedad Española de Nefrología.Öğe In vitro bactericidal effect of Ho:YAG laser and pneumatic lithotripsy on ureteral stones colonized with Escherichia coli and Enterococcus faecalis(Springer Verlag, 2019) Savcı, Ünsal; Sungur, Mustafa; Şahin, Mustafa; Eser, Barış; Çalışkan, SelahattinThe endoscopic treatment of urolithiasis has a high success rate and the complications decreased after the development of lithotripsy techniques. The aim of this study is to investigate the in vitro bactericidal effect of laser and pneumatic lithotripsy on urinary stones colonized with Escherichia coli and Enterococcus faecalis. A total of 40 natural calcium oxalate stones, which were obtained from the patients’ urinary systems with rigid ureteroscopy were used in the study. Surfaces of the stones were colonized with E. coli and E. faecalis strains. The fragmentation of the stones was performed using holmium:yttrium-aluminum-garnet laser (Ho:YAG laser) and pneumatic lithotripters in vitro in Eppendorf tubes filled with liquid. After fragmentation, samples taken from Eppendorf tubes were inoculated on blood and EMB agar. The number of colonies was evaluated after 18–24-hour incubation period. The laser lithotripsy technique reduced the number of colonies by 100% and had bactericidal effect on E. coli and E. faecalis. Pneumatic lithotripsy technique had no bactericidal effect on these strains (0%). In the fifth minute of laser irradiation, the average temperature in the Eppendorf tube was 51–55 °C, and the average temperature in the tenth minute was 54–60 °C. The temperatures did not change in the fifth and tenth minutes with the pneumatic lithotripsy procedure. The present study revealed the bactericidal effect of Ho:YAG laser on E. coli and E. faecalis in vitro. Increased ambient temperature during Ho:YAG laser lithotripsy is thought to play a role in the bactericidal effect. But the question of whether an ideal lithotripter efficiently inactivates or destroys bacteria has still not been answered in urology practice. This preliminary study showed the bactericidal effect of Ho:YAG laser lithotripsy, but further studies are needed to investigate the bactericidal effect of Ho:YAG laser in vivo. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.Öğe Is acquired arterial-venous fistula related to Kaposi sarcoma?(Elsevier Espana S.L., 2017) Eser, Barış; Yayar, Özlem; Doğan, İbrahim; Baş, YılmazKaposi's sarcoma (KS) is a rare inflammatory neoplasia originating from angiogenic vascular endothelial cells.1 Human herpes virus-8 (HHV-8) is considered as a possible cause. KS is often observed in immunocompromised patients such as organ transplant or acquired immunodeficiency syndromes.2 However, although not typical immunosuppression occurs in uraemic patients, various immunologic abnormalities occur.3Öğe Is mean platelet volume a predictor of atherosclerosis in hemodialysis patients?(2017) Yayar, Özlem; Eser, Barış; Bıçakcı, Fahrettin; Aylı, Mehmet DenizAim: Cardiovascular (CV) mortality accounts for the 45% of all mortality in dialysis. Carotid intima-media thickness (CIMT) is aIs mean platelet volume a predictor of atherosclerosis in hemodialysis patients? preclinical marker for CV disease. Activated platelets pose important part of the cellular component in the pathophysiology of atherothrombosis. Mean platelet volume (MPV) is a parameter that indicates the activation of platelets and assessed by studies in various patient groups in atherosclerosis. The aim of this study is to determine the relation of MPV with CIMT in haemodialysis (HD) patients without a history of atherosclerosis. Material and Methods: Eighty two HD patients and 20 healthy individuals were enrolled in this cross-sectional study. Ultrasonographical B-mode imaging of bilateral carotid arteries was performed with a high resolution real-time ultrasonography with 12MHz linear- assay transducer (Mindray DC7). The value was expressed as an average of the maximal CIMT. MPV was measured by automated devices. Results: CIMT was found to be higher in study population when compared to control group. MPV was not different between groups (8.40±0.85 vs 8.4±0.81; P>0.05). In correlation analysis CIMT was found to be positively correlated with age(r=0.326; P=0.003), ALP(r=0.309; P=0.005) and MPV(r=0.26; p= 0,017). Patients were grouped according to median levels of MPV. The patients having higher MPV values were found to have higher PTH (533.9 ± 458.3 vs 845.8 ± 860.2; P<0, 05) and CIMT (0.8 ± 0.1 vs 0.9 ± 0.2; P<0. 05) values. Conclusions: MPV was found to be correlated with CIMT in HD patients. MPV can be used as a marker in HD patients for determining atherosclerosis.Öğe Is oxidative stress associated with total kidney volume in patients with autosomal dominant polycystic kidney disease?(Oxford Univ Press, 2020) Doğan, İbrahim; Eser, Barış; Aydemir, Nihal; Kayadibi, Hüseyin; Özcan, Oğuzhan; Fidan, Nurdan; Özkurt, SultanBackground and Aims : Ischemia Modified Albumin (IMA) is a marker of cardiovascular risk factor associated with oxidative stress. In this study, our aim was to determine oxidative stress status in autosomal dominant polycystic kidney disease (ADPKD) and to evaluate its relationship with total renal volume.Öğe Microscopic Polyangiitis Nodosa: A Rare Cause of Cerebral Hemorrhage(2019) Eser, Barış; Koyun, Osman Nuri; Doğan, İbrahim; Şahin, Mustafa; Çolak, Aysel; Özkayar, NihalMicroscopic polyangiitis nodosa (MPA) is a necrotizing vasculitis that affects small vessels, typically associated with myeloperoxidase anti-neutrophil cytoplasmic antibody. Cerebrovascular diseases are rarely reported to be associated with MPA. A 41-year-old male patient presented to the emergency room with complaints of speech difficulty and loss of strength on the left upper extremity, and MPA was detected with cerebral hemorrhage and renal failure. The case report, just as we first defined with this case in the national literature, was presented to emphasize that MPA may be rarely demonstrated with symptoms of cerebrovascular involvement except for commonly seen organ involvement.Öğe Rare cause of acute kidney injury associated with rhabdomyolysis: quail meat consumption(Blackwell Publishing Ltd, 2016) Doğan, İbrahim; Eser, Barış; Şeker, AyşeDear Editor Acute rhabdomyolysis syndrome is a condition that may lead to electrolyte anomalies, acidosis, hypovolemia and hemoglobinuric renal failure. The most common reasons behind this syndrome are direct muscle damages, and toxic, ischemic, infectious, inflammatory or metabolic disorders 1. One of the rare reasons is food poisoning as a result of eating quail meat 1, 2. The purpose of this letter is to discuss the development of acute rhabdomyolysis after quail meat consumption in two casesÖğe Rare complication in tenchkoff catheter insertion: placement in the bladder(Türk Nefroloji Derneği, 2017) Eser, Barış; Doğan, İbrahim; Yayar, Özlem; Çalışkan, SelahattinMechanical and technical complications associated with a peritoneal dialysis catheter are seen frequently but inserting the catheter into the bladder is a rare complication. The Tenchkoff catheter was inserted into the bladder accidentally in a 64-year-old male patient and this complication was understood by the beginning of peritoneal dialysis (PD). This is the first case reported in the national literature. It is presented to highlight the importance of this complication that may be asymptomatic until the initiation of PD treatment.Öğe Relation between high serum hepcidin-25 level and subclinical atherosclerosis and cardiovascular mortality in hemodialysis patients(Turkish Society of Cardiology, 2018) Yayar, Özlem; Eser, Barış; Kılıç, HarunObjective: In hemodialysis (HD) patients, cardiovascular disease (CVD) is the major cause of mortality and morbidity. In atherosclerotic diseases, iron gets accumulated in the arterial wall. Hepcidin is an important hormone in iron metabolism. Furthermore, hepcidin is associated with atherosclerotic disease. Therefore, this study aims to investigate the relation of serum hepcidin-25 (SH-25) and sub-clinic atherosclerosis measured by carotid intima-media thickness (CIMT) and mortality in HD patients. Methods: We enrolled 82 HD patients in a cross-control study. We measured SH-25 using ELISA kit and CIMT using high-resolution real-time ultra-sonography. After 4 years of first assessment, we investigated the relation between all-cause and cardiovascular mortality and SH-25 and CIMT. Results: Two patients were excluded because of renal transplantation. The survivors were younger (53.7±15.1 vs. 65.2±15.5; p<0.05) and CIMT was lower (0.83±0.2 vs. 0.95±0.2; p<0.05); however, there was no significant difference in SH-25 levels between the groups (29.1±13 vs. 32.4±22.4; p=0.767). The patients who died of CVD were significantly older (63.7±16.1 vs. 53.7±15.1; p<0.05) and had significantly higher CIMT (0.94±0.2 vs. 83±0.2; p<0.05). The SH-25 levels were statistically significantly higher in patients who died of CVD (40.3±25 vs. 29.1±13; p<0.05). Linear regression analysis showed a positive correlation between CIMT and SH-25 in the study population and in those who died from CVD (r=0.41; p<0.05 and r=0.606; p<0.05, respectively). Conclusion: This study suggests that hepcidin is effective in cardiovascular mortality and pathophysiology of subclinical atherosclerosis in HD patients. (Anatol J Cardiol 2018; 19: 117-22) © 2018 by Turkish Society of Cardiology.Öğe Relation of serum ADMA, Apelin-13 and LOX-1 levels with inflammatory and echocardiographic parameters in hemodialysis patients(Wiley, 2018) Doğan, İbrahim; Doğan, Tolga; Yetim, Mücahit; Kayadibi, Hüseyin; Yılmaz, Mehmet Bertan; Eser, Barış; Kalçık, Macit; Karavelioğlu, YusufCardiovascular diseases are the leading causes of mortality in patients with chronic kidney disease. Nitric oxide has a critical role in both endothelial dysfunction and the atherosclerosis process. We aimed to investigate the relationships between serum asymmetric dimethyl arginine (ADMA), LOX-1, and Apelin-13 levels, which are known to act over nitric oxide with endothelial dysfunction and cardiac morphology as well as with each other in hemodialysis patients. The study comprised a total of 120 patients (53 females and 67 males) receiving hemodialysis three times a week for at least 6 months and an age-gender matched control group (55 females and 58 males). Serum ADMA, LOX-1, and Apelin-13 levels were measured using the ELISA technique. Echocardiography, 24-h blood pressure monitoring by the Holter and carotid artery intima-media thickness (CIMT) measurement was performed on all of the included subjects. The associations between serum ADMA, LOX-1, and Apelin-13 levels with CIMT, echocardiographic parameters [left ventricular mass (LVM) and left ventricular mass index (LVMI)], and inflammatory markers [high sensitive C-reactive protein (hsCRP) and neutrophil lymphocyte ratio (NLR)] were evaluated by correlation analysis. Serum ADMA, Apelin-13, and LOX-1 levels were significantly higher in the hemodialysis group than the controls (P < 0.001, P < 0.001, and P < 0.001, respectively). CIMT, hsCRP, and NLR levels were also significantly higher in the hemodialysis group (P < 0.05, P < 0.001, P < 0.001, respectively). Significant correlations were observed among the serum ADMA, Apelin-13, and LOX-1 levels. Moreover, notably positive correlations were found between these three biochemical markers and LVM, LVMI, hsCRP, and CIMT. Serum ADMA, Apelin-13, and LOX-1 levels can be indicators not only for the inflammatory process but also for the pathogenesis of cardiovascular diseases in hemodialysis patients. © 2017 International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis TherapyÖğe Relation of serum spondin-2 levels with cardiac morphology and inflammatory parameters in hemodialysis patients(Springer Netherlands, 2018) Doğan, İbrahim; Yetim, Mücahit; Doğan, Tolga; Kayadibi, Hüseyin; Yılmaz, Mehmet Bertan; Eser, Barış; Kalçık, Macit; Karavelioğlu, YusufPurpose: Cardiovascular diseases are the leading causes of mortality in chronic kidney disease. Spondin-2 (SP-2), an intrinsic cardio-protective factor, prevents maladaptive remodeling. We aimed to determine the relation between serum SP-2 levels and cardiac morphology along with inflammatory parameters in hemodialysis (HD) patients. Method: The study comprised a total of 95 patients (61 females) receiving HD treatment three times a week for at least 6 months, and a control group consisting of age and gender matched 62 subjects (34 females). SP-2 levels were determined by ELISA. Echocardiography, 24-h ambulatory blood pressure monitoring, and carotid artery intima-media thickness (CIMT) measurement were performed in all subjects. The relation of serum SP-2 levels with CIMT, echocardiographic parameters, CRP, and absolute neutrophil-to-lymphocyte count ratio (NLR) was evaluated by correlation analysis. Results: SP-2 levels were found to be significantly higher in the HD group than the control group (16.660 [8.719–20.938] vs. 3.988 [2.702–8.042] ng/L; P < 0.001). CIMT, CRP, and NLR were also higher in HD group (P < 0.005, P < 0.001, and P < 0.001, respectively). Significantly positive correlation was found between SP-2 and left ventricular mass, left ventricular mass index, CRP, and NLR, but no correlation was determined between SP-2 and CIMT. SP-2 was not statistically significant variable for the determination of LVH in univariate logistic regression analysis [Wald = 2.375; OR (95% CI) = 1.000 (0.999–1.000), P = 0.123]. Conclusion: Serum SP-2 levels were higher in HD patients compared to the population with normal renal functions. The results suggest that SP-2, an uremic toxin, might be effective over a complex pathway in the inflammatory process and in the pathogenesis of cardiovascular diseases of patients under HD treatment. © 2018, Springer Nature B.V.Öğe Relationship between peritoneal permeability withinflammation and subclinical atherosclerosis inperitoneal dialysis patients(İnönü Üniversitesi, 2018) Yayar, Özlem; Eser, Barış; Bozkurt, AlperAim: High permeability in peritoneal dialysis (PD) is reported to be associated with increased mortality. Cardiovascular disease is the most important cause of morbidity and mortality in patients with end-stage renal disease. The inflammation is thought to take part in development of atherosclerosis. The aim of this study is to investigate the relation of peritoneal permeability type with carotid intima media thickness (CIMT) in PD patients. Material and Methods: Based on the standard peritoneal equilibration test, 56 PD patients (28 male) were divided in two transporter groups: low (low+low average) and high (high+high average) permeability. C-reactive protein (CRP) measured as a marker of inflammation and CIMT was evaluated by high-resolution B-mode ultrasonography. Results: Twenty one patients were low and 35 of them were high peritoneal transporters. Mean CRP level was significantly higher in the high permeability group (HPG) (1.62±1.7 vs 0.84±1 mg/dL; p=0.006). CIMT was higher in the HPG but this difference did not reach statistical significance (0.810±0.160 vs 0.740±0.160 mm; p=0.16). Conclusions: CRP, an indicator of inflammation, was found to be higher in the HPG. CIMT also was found to be higher in HPG although it was not statistically significant. One of the causes of increased mortality rate in this group of patients may be explained by inflammation and atherosclerosis.Öğe Relationship between renal tubulointerstitial fibrosis and serum prolidase enzyme activity(Walter De Gruyter Gmbh, 2020) Eser, Barış; Doğan, İbrahim; Komut, Erdal; Koyuncu, Sümeyra; Aydemir, Nihal; Çolak, Aysel; Kayadibi, HüseyinObjectives: The severity of interstitial fibrosis/tubular atrophy (IFTA) is the most important determinant of the irreversible progression of chronic kidney disease (CKD). Prolidase is the key enzyme in collagen turnover and is associated with an extracellular matrix increase. We aimed to evaluate the relationship between the presence and degree of IFTA and serum prolidase enzyme activity (SPEA) in patients undergoing a renal biopsy. Methods: This cross-sectional study included 56 patients who underwent a renal biopsy (30 males; mean age 45.3 +/- 16.8 years) and also 54 healthy volunteers (21 males; mean age 42.7 +/- 8.2 years). IFTA scoring was performed on the basis of percentage of IFTA presence in renal biopsy tissues (1=<10%; 2=10-24%; 3=25-50%; 4=>50%). SPEA was measured by spectrophotometric method. Results: The proteinuria and SPEA levels of the patients were significantly higher than the controls (p<0.001 and p<0.001, respectively). SPEA decreased significantly when the IFTA score increased (p<0.002). In the correlation analysis, the IFTA score was negatively correlated with SPEA (r(s)=-0.461, p<0.001), and positively correlated with proteinuria (r(s)=0.274, p=0.041). Conclusion: These findings suggest that increased collagen turnover decreases over time concerning the progression of renal fibrosis. Monitoring of SPEA level may useful as a biomarker for early determination of CKD progression and severity.Öğe Relationship of serum asymmetric dimethylarginine levels with inflammation and cardiac functions in autosomal dominant polycystic kidney disease(Turkish Society of Nephrology, 2018) Doğan, İbrahim; Altuner, Şakir; Kahvecioğlu, Serdar; Hünük, Ahmet; Eser, Barış; Yayar, Özlem; Kurtoğlu, Ünal; Bayol, HakanOBJECTIVE: Most deaths in autosomal dominant polycystic kidney disease (ADPKD) are attributable to cardiovascular disease (CVD). The relationship between serum asymmetric dimethylarginine (ADMA) and CVD has been investigated. We aimed to search the relationship between serum ADMA, atherosclerosis, inflammation and cardiac functions in ADPKD. MATERIAL and METHODS: Fifty-seven ADPKD patients and 23 healthy control subjects were enrolled. Carotid artery intima-media thickness (CIMT) and echocardiographic measurements were performed. ADMA, inflammatory markers, Neutrophil Count/Lymphocyte Count (NLR), echocardiographic findings and CIMT values were compared between the groups. Correlation analyses were performed. RESULTS: ADMA levels were lower in patients compared to controls [10106 ng/L (2010-60000) vs. 20161 ng/L (2902-60000), p=0.006]. CIMT was 0.67±0.03 mm in the patient group and 0.62±0.03 mm in the control group (p>0.05). In the patient group, left ventricular mass (LVM), left ventricular mass index (LVMI), left atrial diameter (LAD) and left ventricular end-diastolic diameter (LVEDD) values were higher (p<0.001, p<0.001, p<0.05, p<0.01). NLR was 2.0 (0.96-13) in the patient group and 1.6 (0.81-6.06) in the control group (p<0.01). Serum ADMA levels were negatively correlated with CIMT and LAD (p<0.05, p<0.001). CONCLUSION: Serum ADMA levels were found to be low in ADPKD patients. Additional studies are needed to determine the possible affect of ADMA on atherosclerosis and inflammation in early stage of ADPKD. © 2018 Turkish Society of Nephrology. All rights reserved.Öğe Serum ADMA, endothelial dysfunction, and atherosclerosis in hypervolemic hemodialysis patients(TÜBİTAK, 2018) Doğan, İbrahim; Eser, Barış; Özkurt, Sultan; Yayar, Özlem; Özgür, Bülent; Kayadibi, Hüseyin; Doğan, Tolga; Musmul, Ahmet; Soydan, MehmetBackground/aim: Asymmetric dimethyl arginine (ADMA) is a strong predictor of cardiovascular disease and mortality in patients under hemodialysis treatment. We aimed to investigate the relationship among volume status, endothelial dysfunction, and ADMA in hemodialysis patients. Materials and methods: A total of 120 patients with a history of hemodialysis treatment were included. ADMA and CRP were measured. Echocardiographic evaluation and carotid artery intima–media thickness (CIMT) measurements were performed. Patients were divided into two groups according to clinical evaluation, ultrafiltration rate, vena cava inferior diameter (VCI), and cardiothoracic index (CTI); the two groups were hypervolemic and normovolemic. Results: The hypervolemic group included 61 patients while the normovolemic group included 59 patients. CIMT was higher in the hypervolemic group, but this result was not statistically significant (0.95 mm versus 0.85 mm, P = 0.232). There was a statistically significant difference between the hypervolemic and normovolemic groups in terms of ADMA (P < 0.001) (0.69 ± 0.57 µmol/L and 0.41 ± 0.04 µmol/L, respectively). Positive correlations were observed between serum ADMA, VCI, CTI, CRP, CIMT, and cardiac mass (P < 0.001, P = 0.016, P < 0.001, P = 0.006, P = 0.022, respectively), and negative correlations were observed between ADMA and ejection fraction and albumin (P = 0.024, P = 0.024, respectively). In multiple linear regression analysis, ADMA was independently associated with age, systolic blood pressure, CTI, and volume status. Conclusion: ADMA may be a potential determinant of hypervolemia as well as atherosclerosis in patients under hemodialysis treatment. © TÜBİTAK.
