Relationship between renal tubulointerstitial fibrosis and serum prolidase enzyme activity
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Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Walter De Gruyter Gmbh
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: The severity of interstitial fibrosis/tubular atrophy (IFTA) is the most important determinant of the irreversible progression of chronic kidney disease (CKD). Prolidase is the key enzyme in collagen turnover and is associated with an extracellular matrix increase. We aimed to evaluate the relationship between the presence and degree of IFTA and serum prolidase enzyme activity (SPEA) in patients undergoing a renal biopsy. Methods: This cross-sectional study included 56 patients who underwent a renal biopsy (30 males; mean age 45.3 +/- 16.8 years) and also 54 healthy volunteers (21 males; mean age 42.7 +/- 8.2 years). IFTA scoring was performed on the basis of percentage of IFTA presence in renal biopsy tissues (1=<10%; 2=10-24%; 3=25-50%; 4=>50%). SPEA was measured by spectrophotometric method. Results: The proteinuria and SPEA levels of the patients were significantly higher than the controls (p<0.001 and p<0.001, respectively). SPEA decreased significantly when the IFTA score increased (p<0.002). In the correlation analysis, the IFTA score was negatively correlated with SPEA (r(s)=-0.461, p<0.001), and positively correlated with proteinuria (r(s)=0.274, p=0.041). Conclusion: These findings suggest that increased collagen turnover decreases over time concerning the progression of renal fibrosis. Monitoring of SPEA level may useful as a biomarker for early determination of CKD progression and severity.
Açıklama
Anahtar Kelimeler
Chronic kidney disease, Collagen turnover, Prolidase enzyme activity, Proteinuria, Tubulointerstitial fibrosis
Kaynak
Turkish Journal Of Biochemistry-Turk Biyokimya Dergisi
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
45
Sayı
5
Künye
Eser, B., Dogan, I., Komut, E., Koyuncu, S., Aydemir, N., Colak, A., ... & Kayadibi, H. (2020). Relationship between renal tubulointerstitial fibrosis and serum prolidase enzyme activity. Turkish Journal of Biochemistry, 45(5), 567-573.
