Relationship between renal tubulointerstitial fibrosis and serum prolidase enzyme activity

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dc.authoridEser, Barış / 0000-0003-2025-2013
dc.authoridDoğan, İbrahim / 0000-0001-8489-4985
dc.authoridAydemir, Nihal / 0000-0002-9086-7024
dc.authoridÇolak, Ayşe / 0000-0002-0771-9128
dc.authoridAkgün, Hülya / 0000-0002-0513-0045
dc.authoridKayadibi, Hüseyin / 0000-0002-3922-4517
dc.contributor.authorEser, Barış
dc.contributor.authorDoğan, İbrahim
dc.contributor.authorKomut, Erdal
dc.contributor.authorKoyuncu, Sümeyra
dc.contributor.authorAydemir, Nihal
dc.contributor.authorÇolak, Aysel
dc.contributor.authorKayadibi, Hüseyin
dc.date.accessioned2021-11-01T15:05:05Z
dc.date.available2021-11-01T15:05:05Z
dc.date.issued2020
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.departmentHitit Üniversitesi, Sağlık Bilimleri Fakültesi, Sağlık Yönetimi Bölümü
dc.description.abstractObjectives: The severity of interstitial fibrosis/tubular atrophy (IFTA) is the most important determinant of the irreversible progression of chronic kidney disease (CKD). Prolidase is the key enzyme in collagen turnover and is associated with an extracellular matrix increase. We aimed to evaluate the relationship between the presence and degree of IFTA and serum prolidase enzyme activity (SPEA) in patients undergoing a renal biopsy. Methods: This cross-sectional study included 56 patients who underwent a renal biopsy (30 males; mean age 45.3 +/- 16.8 years) and also 54 healthy volunteers (21 males; mean age 42.7 +/- 8.2 years). IFTA scoring was performed on the basis of percentage of IFTA presence in renal biopsy tissues (1=<10%; 2=10-24%; 3=25-50%; 4=>50%). SPEA was measured by spectrophotometric method. Results: The proteinuria and SPEA levels of the patients were significantly higher than the controls (p<0.001 and p<0.001, respectively). SPEA decreased significantly when the IFTA score increased (p<0.002). In the correlation analysis, the IFTA score was negatively correlated with SPEA (r(s)=-0.461, p<0.001), and positively correlated with proteinuria (r(s)=0.274, p=0.041). Conclusion: These findings suggest that increased collagen turnover decreases over time concerning the progression of renal fibrosis. Monitoring of SPEA level may useful as a biomarker for early determination of CKD progression and severity.
dc.identifier.citationEser, B., Dogan, I., Komut, E., Koyuncu, S., Aydemir, N., Colak, A., ... & Kayadibi, H. (2020). Relationship between renal tubulointerstitial fibrosis and serum prolidase enzyme activity. Turkish Journal of Biochemistry, 45(5), 567-573.
dc.identifier.doi10.1515/tjb-2020-0026
dc.identifier.endpage573en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85096942252
dc.identifier.scopusqualityQ3
dc.identifier.startpage567en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2020-0026
dc.identifier.urihttps://hdl.handle.net/11491/7096
dc.identifier.volume45en_US
dc.identifier.wosWOS:000582568000013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorEser, Barış
dc.institutionauthorDoğan, İbrahim
dc.institutionauthorKomut, Erdal
dc.institutionauthorAydemir, Nihal
dc.institutionauthorKayadibi, Hüseyin
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofTurkish Journal Of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChronic kidney diseaseen_US
dc.subjectCollagen turnoveren_US
dc.subjectProlidase enzyme activityen_US
dc.subjectProteinuriaen_US
dc.subjectTubulointerstitial fibrosisen_US
dc.titleRelationship between renal tubulointerstitial fibrosis and serum prolidase enzyme activity
dc.typeArticle

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