Investigation of mindin levels in hypertensive patients with left ventricular hypertrophy and QRS fragmentation on electrocardiography

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dc.contributor.authorDoğan, Tolga
dc.contributor.authorYetim, Mücahit
dc.contributor.authorÇelik, Oğuzhan
dc.contributor.authorKalçık, Macit
dc.contributor.authorÖzcan, Oğuzhan
dc.contributor.authorDoğan, İbrahim
dc.contributor.authorErenler, Ali Kemal
dc.contributor.authorBekar, Lütfü
dc.contributor.authorKaravelioğlu, Yusuf
dc.date.accessioned2019-05-10T09:38:45Z
dc.date.available2019-05-10T09:38:45Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractPurpose: Mindin was associated with diabetic nephropathy, podocyte injury, colitis, allergic asthma, liver ischaemia and reperpusion injury and ischaemic brain injury. On the other hand, it was reported as a protective factor against obesity, cardiac hypertrophy, fibrosis and remodelling. Fragmented QRS complexes (fQRS) are markers of altered ventricular depolarisation owing to a prior myocardial scar and fibrosis. In this study, we aimed to investigate mindin levels in hypertensive patients with left ventricular hypertrophy and fQRS on electrocardiography. Methods: This observational case-control study enrolled 70 (36 female) hypertensive patients with fQRS and 38 (23 female) hypertensive control patients. All patients were evaluated by transthoracic echocardiography. Mindin levels were measured by the enzyme-linked immunosorbent assay (ELISA). Clinical, echocardiographic and laboratory data were compared between patient and control groups. Results: There was no significant difference between patient and control groups in terms of clinical, echocardiographic and routine laboratory parameters. The mindin levels were significantly higher in the patient group than controls (11.3 (7.21–19.31) vs 4.15 (2.86–6.34); p <.001). Multiple logistic regression analyses defined increased mindin levels as an independent predictor for the presence of fQRS (Odds ratio: 1.733; p =.034). Mindin levels >6.74 predicted the presence of fQRS with a sensitifity of 84.3% and specificity of 79.9% on receiver operating characteristic (ROC) curve analysis (The area under the curve:0.889; Confidence Interval: 0.827–0.951; p <.001). Conclusion: Mindin expressin is upregulated in hypertensive patients with fQRS complexes. In contrary to previous studies, increased mindin levels may be associated with myocardial fibrosis. © 2017, © 2017 Belgian Society of Cardiology.
dc.identifier.citationDoğan, T., Yetim, M., Çelik, O. M., Kalçık, M., Özcan, O., Doğan, İ. V., Erenler, A. K., Bekar, L., Karavelioğlu, Y. (2018). Investigation of mindin levels in hypertensive patients with left ventricular hypertrophy and QRS fragmentation on electrocardiography. Acta cardiologica, 73(6), 544-549.
dc.identifier.doi10.1080/00015385.2017.1418616
dc.identifier.endpage549en_US
dc.identifier.issn0001-5385
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage544en_US
dc.identifier.urihttps://doi.org/10.1080/00015385.2017.1418616
dc.identifier.urihttps://hdl.handle.net/11491/457
dc.identifier.volume73en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofActa Cardiologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEchocardiographyen_US
dc.subjectFibrosisen_US
dc.subjectFragmented QRSen_US
dc.subjectLeft Ventricular Hypertrophyen_US
dc.subjectMindinen_US
dc.titleInvestigation of mindin levels in hypertensive patients with left ventricular hypertrophy and QRS fragmentation on electrocardiography
dc.typeArticle

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