Evaluation of atrial conduction features in stable chronic obstructive pulmonary disease patients and its relationship with neutrophil to lymphocyte ratio

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dc.contributor.authorArısoy, Arif
dc.contributor.authorMemiç, Kadriye
dc.contributor.authorErçen Diken, Özlem
dc.contributor.authorKaravelioğlu, Yusuf
dc.contributor.authorDemirelli, Selami
dc.contributor.authorTopçu, Selim
dc.contributor.authorDe?irmenci, Hüsnü
dc.contributor.authorBakırcı, Eftal Murat
dc.contributor.authorAltunkaş, Fatih
dc.contributor.authorKaraman, Kayıhan
dc.date.accessioned2019-05-13T08:57:32Z
dc.date.available2019-05-13T08:57:32Z
dc.date.issued2015
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractAims: Chronic obstructive pulmonary disease (COPD) has been associated with a high frequency of cardiac arrhythmia. While many studies have examined the development of atrial fibrillation (AF) in COPD patients, there is insufficient data about atrial conduction time (ACT) and its relationship with the Neutrophil to Lymphocyte ratio (NLR) in these patients. The aim of the present study was to evaluate atrial conduction features and its relationship with NLR. Materials and methods: The study groups comprised 40 patients with COPD and 40 healthy subjects, who were subjected to pulmonary function tests, 12-lead surface electrocardiograms, echocardiographic examinations and blood sample tests. ACT was measured through tissue Doppler imaging, while NLR was measured by dividing the neutrophil count by the lymphocyte count. Results: Pulmonary function values were significantly lower in COPD patients than in the control group, as would be expected (p<0,001). According to the ACT measurements, tricuspid ACT was significantly longer in COPD patients than in the controls (26.4 ± 11.4 ms vs 17.7 ± 7.7 ms, p<0.001). Also, NLR was higher in COPD patients than in the control group (2.4 ±1.2 vs 1.94 ±0.8 p=0.009). A negative correlation was observed between tricuspid ACT and the percent of forced expiratory volume in one second (FEV1 %) (r = - 0.45; p <0.001), and a significant positive correlation was identified between tricuspid ACT and NLR (r=+0.38; p< 0.001). Conclusion: Our study revealed prolonged tricuspid ACT and increased NLR in COPD patients, and the existence of a relationship between these parameters was identified. Previous studies claim that hypoxia and chronic inflammation may be the underlying mechanisms explaining arrhythmia in patients with COPD, while many studies also show that a prolongation of ACT and increased NLR is associated with atrial arrhythmias. In the light of our findings and previous data, the assessment of ACT and NLR can be considered a clinically useful approach to detecting the risk of AF development in the population.
dc.identifier.citationArısoy, A., Memiç, K., Erçen Diken, Ö., Karavelioğlu, Y., Demirelli, S., Topcu, S., De?irmenci, H., Bakırcı, E. M.[et.al.]. (2015). Evaluation of atrial conduction features in stable chronic obstructive pulmonary disease patients and its relationship with neutrophil to lymphocyte ratio. Acta Medica Mediterranea, 31(2), 343-349.
dc.identifier.endpage349en_US
dc.identifier.issn0393-6384
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage343en_US
dc.identifier.urihttps://hdl.handle.net/11491/952
dc.identifier.volume31en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherCarbone Editore di Alessandro Pennino
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAtrial Conduction Timeen_US
dc.subjectAtrial Fibrillationen_US
dc.subjectChronic Obstructive Pulmonary Diseaseen_US
dc.subjectNeutrophil to Lymphocyte Ratioen_US
dc.titleEvaluation of atrial conduction features in stable chronic obstructive pulmonary disease patients and its relationship with neutrophil to lymphocyte ratio
dc.typeArticle

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