Ultrastructural and morphometric alterations to the peripheral nerve following the administration of immunosuppressive agent tacrolimus (FK506)

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dc.contributor.authorCelikkan, Ferda Topal
dc.contributor.authorOzyol, Nazli Hayirli
dc.contributor.authorNakkas, Hilal
dc.contributor.authorEvirgen, Oya
dc.date.accessioned2021-11-01T15:05:55Z
dc.date.available2021-11-01T15:05:55Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractTacrolimus, a widely used immunosuppressive drug for preventing graft rejection following organ transplantation, was reported to develop neurotoxic side effects ranging from mild to severe symptoms in the literature. Rats were randomly divided into three groups as control and 2-week and 3-week treatment groups and received a 2 mg/kg/day tacrolimus by oral gavage. Animals were sacrificed and sciatic nerves obtained from all groups were fixed and processed for light and electron microscopic investigations. The myelinated fiber diameter, axon diameter, G-ratio (axon diameter/myelinated fiber diameter), and myelin thickness were also determined. The data obtained in the control and tacrolimus-treated groups were compared. The control group sciatic nerve fascicles showed normal morphology with myelinated and unmyelinated fibers. Experimental groups exhibited axonal dilatation, irregularly thickened and vacuolated myelin sheaths with separation of myelin layers. The morphometric analysis showed that the myelinated fibers of the 2-week tacrolimus-treated group displayed a moderate increase in the myelin thickness and axon and fiber diameter in comparison with the control and 3-week tacrolimus-treated groups. The G-ratio was found to be in normal range in all groups and there were no statistically significant difference. The present study indicates that the treatment with tacrolimus may produce a mild degenerative change but prolonged drug administration for 3 weeks led to improvement in morphometric and morphologic data and the normal G-ratio values, suggesting that the regeneration capacity of the myelinated fibers maintains their normal function to transmit nerve impulses.
dc.identifier.doi10.1080/01913123.2021.1881673
dc.identifier.endpage117en_US
dc.identifier.issn0191-3123
dc.identifier.issn1521-0758
dc.identifier.issue2en_US
dc.identifier.pmid33596749
dc.identifier.scopus2-s2.0-85101043101
dc.identifier.scopusqualityQ3
dc.identifier.startpage112en_US
dc.identifier.urihttps://doi.org/10.1080/01913123.2021.1881673
dc.identifier.urihttps://hdl.handle.net/11491/7440
dc.identifier.volume45en_US
dc.identifier.wosWOS:000619073900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofUltrastructural Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectG-ratioen_US
dc.subjectneurotoxic effectsen_US
dc.subjectsciatic nerveen_US
dc.subjecttacrolimus (FK506)en_US
dc.subjectultrastructureen_US
dc.titleUltrastructural and morphometric alterations to the peripheral nerve following the administration of immunosuppressive agent tacrolimus (FK506)
dc.typeArticle

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