Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study

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dc.authoridOrtiz-Fernandez, Lourdes / 0000-0002-0247-4280
dc.authoridKanitez, Nilufer Alpay / 0000-0003-1185-5816
dc.authoridAkkoc, Nurullah / 0000-0002-3718-171X
dc.authoridFresko, Izzet / 0000-0002-8914-9690
dc.authoridCoit, Patrick / 0000-0003-0660-764X
dc.authoridMason, Justin / 0000-0001-7783-1660
dc.authoridOnen, Fatos / 0000-0002-6341-2622
dc.authorwosidOrtiz-Fernandez, Lourdes / AAA-6647-2020
dc.authorwosidKanitez, Nilufer Alpay / W-7332-2019
dc.authorwosidAkkoc, Nurullah / D-9870-2011
dc.contributor.authorOrtiz-Fernandez, Lourdes
dc.contributor.authorSaruhan-Direskeneli, Guher
dc.contributor.authorAlibaz-Oner, Fatma
dc.contributor.authorKaymaz-Tahra, Sema
dc.contributor.authorCoit, Patrick
dc.contributor.authorKong, Xiufang
dc.contributor.authorSawalha, Amr H.
dc.date.accessioned2021-11-01T15:06:18Z
dc.date.available2021-11-01T15:06:18Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractTakayasu arteritis is a rare inflammatory disease of large arteries. We performed a genetic study in Takayasu arteritis comprising 6,670 individuals (1,226 affected individuals) from five different populations. We discovered HLA risk factors and four non-HLA susceptibility loci in VPS8, SVEP1, CFL2, and chr13q21 and reinforced IL12B, PTK2B, and chr21q22 as robust susceptibility loci shared across ancestries. Functional analysis proposed plausible underlying disease mechanisms and pinpointed ETS2 as a potential causal gene for chr21q22 association. We also identified >60 candidate loci with suggestive association (p < 5 x 10(-s)) and devised a genetic risk score for Takayasu arteritis. Takayasu arteritis was compared to hundreds of other traits, revealing the closest genetic relatedness to inflammatory bowel disease. Epigenetic patterns within risk loci suggest roles for monocytes and B cells in Takayasu arteritis. This work enhances understanding of the genetic basis and pathophysiology of Takayasu arteritis and provides clues for potential new therapeutic targets.
dc.description.sponsorshipNational Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) [R01 AR070148]; National Institute of Arthritis and Musculoskeletal and Skin DiseasesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) [U54 AR057319, U01 AR51874 04]; National Center for Research ResourcesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Research Resources (NCRR) [U54 RR019497]; Office of Rare Diseases Research of the National Center for Advancing Translational Sciences; Imperial College, National Institute for Health Research, Biomedical Research Centre; Wellcome TrustWellcome TrustEuropean Commission [WT107881]; Medical Research CouncilUK Research & Innovation (UKRI)Medical Research Council UK (MRC)European Commission [MC_UU_00002/4]en_US
dc.description.sponsorshipThis work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health grant R01 AR070148 to A.H.S. The Vasculitis Clinical Research Consortium has received support from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319 and U01 AR51874 04), the National Center for Research Resources (U54 RR019497), and the Office of Rare Diseases Research of the National Center for Advancing Translational Sciences. J.C.M., A.P.K., and R.M.M. acknowledge support from the Imperial College, National Institute for Health Research, Biomedical Research Centre. C.W. and G.R. acknowledge support from The Wellcome Trust (WT107881) and the Medical Research Council (MC_UU_00002/4). This work was supported by the use of study data downloaded from the dbGaP website, under dbGaP: phs000272.v1.p1, phs000431.v2.p1, phs000583.v1.p1, and phs000444.v1.p1.en_US
dc.identifier.doi10.1016/j.ajhg.2020.11.014
dc.identifier.endpage99en_US
dc.identifier.issn0002-9297
dc.identifier.issn1537-6605
dc.identifier.issue1en_US
dc.identifier.pmid33308445
dc.identifier.scopus2-s2.0-85098505408
dc.identifier.scopusqualityQ1
dc.identifier.startpage84en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajhg.2020.11.014
dc.identifier.urihttps://hdl.handle.net/11491/7538
dc.identifier.volume108en_US
dc.identifier.wosWOS:000606453800008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherCell Press
dc.relation.ispartofAmerican Journal Of Human Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject[No Keywords]en_US
dc.titleIdentification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study
dc.typeArticle

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