Analytical and preparative scale separation of enantiomers of chiral drugs by chromatography and related methods

Basit Öğe Kaydı
dc.authorid0000-0003-2793-7154
dc.authorid0000-0001-7494-3077
dc.contributor.authorGümüştaş, Mehmet
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.contributor.authorChankvetadze, Bezhan
dc.date.accessioned2019-05-13T08:58:10Z
dc.date.available2019-05-13T08:58:10Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractWhile the amino acids, enzymes and hormones are chiral, chirality plays significant role in the life of plants, animals, as well as the human being. Chirality of molecules is important in various industries, such as pharmaceutical, agricultural, food, electronics, etc. Chiral drugs may have different bioavailability, distribution, biotransformation and excretion, as well as quantitatively and/or qualitatively different pharmacological or toxic properties. Enantiomerically pure chiral drugs have been increasingly developed for the pharmaceutical market due to their superiority from the viewpoints of potency and safety. This is supported by the development of new methods for enantioselective production of the chiral compounds, as well as by the capability of the enantioselective analytical methods to allow a detection and quantification of minor enantiomeric impurity in the presence of another enantiomer in a large excess. The aim of the present review is to provide a short summary of the basic principles of chiral separations on an analytical and preparative scale. In addition, some selected applications for analytical techniques, such as gas chromatography, supercritical fluid chromatography, high performance liquid chromatography, capillary electrophoresis and capillary electrochromatography for the separation of enantiomers of chiral pharmaceuticals published in the last two years are also discussed. © 2018 Bentham Science Publishers.
dc.identifier.citationGumustas, M., Ozkan, S. A., & Chankvetadze, B. (2018). Analytical and preparative scale separation of enantiomers of chiral drugs by chromatography and related methods. Current medicinal chemistry, 25(33), 4152-4188.
dc.identifier.doi10.2174/0929867325666180129094955
dc.identifier.endpage4188en_US
dc.identifier.issn0929-8673
dc.identifier.issue33en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage4152en_US
dc.identifier.urihttps://doi.org/10.2174/0929867325666180129094955
dc.identifier.urihttps://hdl.handle.net/11491/1084
dc.identifier.volume25en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBentham Science Publishers B.V.
dc.relation.ispartofCurrent Medicinal Chemistry
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnalytical Scaleen_US
dc.subjectChiral Drugsen_US
dc.subjectChiralityen_US
dc.subjectEnantioseparationsen_US
dc.subjectPreparative Scaleen_US
dc.subjectSeparation of Enantiomersen_US
dc.titleAnalytical and preparative scale separation of enantiomers of chiral drugs by chromatography and related methods
dc.typeReview Article

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