Cholesterol removal via cyclodextrin-decoration on cellulose nanocrystal (CNC)-grafted poly(HEMA-GMA) nanocomposite adsorbent
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Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Glycidyl methacrylate (GMA) was grafted to cellulose nanocrystals (CNCs) using hydroquinone resulting in a crosslinkable nanoparticle. 2-Hydroxyethyl methacrylate (HEMA) was used to polymerize this nanoparticle to obtain a polymeric structure with a bridging CNC structure to which cyclodextrin (CD) was attached in order to better capture hydrophobic biomolecules. X-Ray Microscopy and nuclear magnetic resonance methods provided the main characterization data proving the successful modification process. This CD-modified nanocomposite adsorbent was used for the removal of cholesterol and low-density lipoprotein for the first time. Adsorption performance in a continuous system was similar to 99% for both cholesterol and low-density lipoprotein with agreement between experimental data and mathematical models performed. Overall, results indicate that cyclodextrin modified poly(HEMA-GMA-g-CNC) is a promising material for use as an adsorbent for biological and biomedical applications.
Açıklama
Anahtar Kelimeler
Cellulose nanomaterial, Cyclodextrin, Cholesterol, Low density lipoprotein, Removal
Kaynak
Cellulose
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
28
Sayı
1
