Cholesterol removal via cyclodextrin-decoration on cellulose nanocrystal (CNC)-grafted poly(HEMA-GMA) nanocomposite adsorbent

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dc.authoridKose, Kazim / 0000-0003-1467-2898
dc.authorwosidKose, Kazim / A-3531-2016
dc.authorwosid/ ABI-3951-2020
dc.contributor.authorKose, Kazim
dc.contributor.authorMavlan, Miran
dc.contributor.authorUzun, Lokman
dc.contributor.authorYoungblood, Jeffry P.
dc.date.accessioned2021-11-01T15:06:02Z
dc.date.available2021-11-01T15:06:02Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractGlycidyl methacrylate (GMA) was grafted to cellulose nanocrystals (CNCs) using hydroquinone resulting in a crosslinkable nanoparticle. 2-Hydroxyethyl methacrylate (HEMA) was used to polymerize this nanoparticle to obtain a polymeric structure with a bridging CNC structure to which cyclodextrin (CD) was attached in order to better capture hydrophobic biomolecules. X-Ray Microscopy and nuclear magnetic resonance methods provided the main characterization data proving the successful modification process. This CD-modified nanocomposite adsorbent was used for the removal of cholesterol and low-density lipoprotein for the first time. Adsorption performance in a continuous system was similar to 99% for both cholesterol and low-density lipoprotein with agreement between experimental data and mathematical models performed. Overall, results indicate that cyclodextrin modified poly(HEMA-GMA-g-CNC) is a promising material for use as an adsorbent for biological and biomedical applications.
dc.description.sponsorshipTUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [1059B191601290]; EVPRP Major Multi-User Equipment Program 2017 at Purdue Universityen_US
dc.description.sponsorshipWe were hugely indebted to TUBITAK for the support with a 2219-International Postdoctoral Research Fellowship Program with a Grant Number: 1059B191601290. We acknowledge Chven Mitchell who assisted/acquired the images of CD-modified poly(HEMA-GMA-g-CNC) for this study on a Zeiss Xradia 510 Versa 3D X-ray Microscope that was supported by the EVPRP Major Multi-User Equipment Program 2017 at Purdue University. We also acknowledge Md Nuriddin who assisted/acquired the FT-IR data and images of CD-modified poly(HEMA-GMA-g-CNC) for this study on a Nicolet Magna-IR Spectrometer 550 series II (USA) and Pro X PHENOM TM (Phenom-World~, Netherlands) Electron Microscope at Purdue University, respectively.en_US
dc.identifier.doi10.1007/s10570-020-03534-7
dc.identifier.endpage487en_US
dc.identifier.issn0969-0239
dc.identifier.issn1572-882X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85095433184
dc.identifier.scopusqualityQ1
dc.identifier.startpage471en_US
dc.identifier.urihttps://doi.org/10.1007/s10570-020-03534-7
dc.identifier.urihttps://hdl.handle.net/11491/7472
dc.identifier.volume28en_US
dc.identifier.wosWOS:000585754100002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofCellulose
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCellulose nanomaterialen_US
dc.subjectCyclodextrinen_US
dc.subjectCholesterolen_US
dc.subjectLow density lipoproteinen_US
dc.subjectRemovalen_US
dc.titleCholesterol removal via cyclodextrin-decoration on cellulose nanocrystal (CNC)-grafted poly(HEMA-GMA) nanocomposite adsorbent
dc.typeArticle

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