Semi-Purified Saponins of Holothuria poli Associated Antiproliferation in Tumor Cell Lines

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dc.authoridKOZ, OMER / 0000-0002-2882-6811
dc.authorwosidKOZ, OMER / A-7019-2016
dc.contributor.authorMert-Ozupek, Nazli
dc.contributor.authorBasbinar, Yasemin
dc.contributor.authorUysal-Kilic, Tugba
dc.contributor.authorKoz, Omer
dc.contributor.authorEllidokuz, Hulya
dc.contributor.authorCavas, Levent
dc.date.accessioned2021-11-01T15:05:48Z
dc.date.available2021-11-01T15:05:48Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractThe incidence of cancer has exhibited an increasing trend in recent years because of many reasons such as environmental and nutritional factors. There is a great need for the development of new and natural molecules with lower side effects in the therapy of cancer. It was aimed to evaluate the antiproliferative effect of semi-purified triterpene glycosides of Holothuria poli on different human cancer cell lines. The body walls of H. poli as the main sources of saponins were used and the saponin content of the extract was characterized by MALDI-TOF/MS. The antiproliferation activity of the characterized extract was tested on cancer cell lines. The extract showed antiproliferative effect on the studied cancer cell lines. The mass analysis results reveal that Holothurin A is one of the saponins within the extract. The measured IC50 values were found as 31.41 +/- 2.20, 77.45 +/- 0.23, and 34.79 +/- 0.90 mu g mL(-1) for HT-29, UPCI-SCC-131, and T84 cell lines, respectively. H. poli secretes not only specific saponins but also a cocktail of them. Specific versus. cocktails of the saponins and by also applying organic modification must be studied in further research to understand their mechanisms in the antiproliferation studies since this paper reveals promising results.
dc.description.sponsorshipScientific and Technological Research council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114Z211]en_US
dc.description.sponsorshipThis study was funded by The Scientific and Technological Research council of Turkey (TUBITAK) (Grant number: 114Z211).en_US
dc.identifier.doi10.1080/01635581.2021.1952630
dc.identifier.issn0163-5581
dc.identifier.issn1532-7914
dc.identifier.pmid34459328
dc.identifier.scopus2-s2.0-85113783438
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1080/01635581.2021.1952630
dc.identifier.urihttps://hdl.handle.net/11491/7408
dc.identifier.wosWOS:000690863900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherRoutledge Journals, Taylor & Francis Ltd
dc.relation.ispartofNutrition And Cancer-An International Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject[No Keywords]en_US
dc.titleSemi-Purified Saponins of Holothuria poli Associated Antiproliferation in Tumor Cell Lines
dc.typeArticle

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