The protective effect of Ganoderma lucidum on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury

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dc.authoriddogan, gul / 0000-0002-3281-9323
dc.authoridReis, AlessanRSS / 0000-0001-8486-7469
dc.contributor.authorDogan, Gul
dc.contributor.authorIpek, Hulya
dc.date.accessioned2021-11-01T15:03:06Z
dc.date.available2021-11-01T15:03:06Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractPurpose: To investigate the protective effect of Ganoderma lucidum on testicular torsion/detorsion (T/D)-induced ischemia-reperfusion (I/R) injury. Methods: Thirty male Wistar albino rats were randomly categorized into 3 groups: Group 1: sham, Group 2 ( T/D): 2,5 hours of ischemia and 7 days of reperfusion, Group 3 (T/D+G. lucidum): 2,5 hours of ischemia and 7 days of reperfusion and 7 days of 20 mg/kg via gastric gavage G. lucidum polysaccharides per day. Biochemical assays of Malondialdehyde (MDA), superoxide dismutase (SOD), Catalase (CAT), Glutathione (GSH) levels, histopathology and expression levels of VEGF and Bcl-2 with immunohistochemical methods were examined in testicular tissue. Results: G. lucidum treatment was found to have prevented the T/D-induced I/R injury by decreasing MDA levels of the testis. SOD, CAT and GSH activities were decreased in group 2, while they were increased in group 3 (p<0.001) and significant improvement in the tube diameter was observed in group 3. Bcl-2-positive germinal cells were lowered in group 3 compared to the group 2. VEGF expression showed an increase in group 2, whereas it decreased in group 3. Conclusion: The antioxidant G. lucidum is thought to induce angiogenesis by reducing the apoptotic effect in testicular torsion-detorsion.
dc.identifier.doi10.1590/s0102-865020200010000003
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue1en_US
dc.identifier.pmid32215464
dc.identifier.scopus2-s2.0-85082502840
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1590/s0102-865020200010000003
dc.identifier.urihttps://hdl.handle.net/11491/6968
dc.identifier.volume35en_US
dc.identifier.wosWOS:000522161000002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSpermatic Cord Torsionen_US
dc.subjectTestisen_US
dc.subjectReishien_US
dc.subjectVascular Endothelial Growth Factor Aen_US
dc.subjectLymphoma B-Cellen_US
dc.subjectRatsen_US
dc.titleThe protective effect of Ganoderma lucidum on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury
dc.typeArticle

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