Carotid intima-media thickness in chronic obstructive pulmonary disease and survival: A multicenter prospective study

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dc.authoridbeyan, ayse coskun / 0000-0002-3731-2978
dc.authoridturan, onur / 0000-0001-6320-0470
dc.authoridDiken, Ozlem Ercen / 0000-0001-8388-9500
dc.authoridGulbas, Gazi / 0000-0002-9435-8307
dc.authoridDemirci, Nilgun Yilmaz / 0000-0001-6160-3778
dc.authoridOgan, Nalan / 0000-0001-5232-3803
dc.authoridMUTLU, LEVENT CEM / 0000-0002-3535-5704
dc.authorwosidbeyan, ayse coskun / Q-8940-2017
dc.authorwosidturan, onur / P-7431-2015
dc.authorwosidDiken, Ozlem Ercen / AAI-6625-2021
dc.authorwosidDuyar, Sezgi Sahin / AAU-4149-2021
dc.authorwosidGulbas, Gazi / ABI-5182-2020
dc.authorwosidOgan, Nalan / ABB-8400-2020
dc.authorwosidDemirci, Nilgun Yilmaz / C-9348-2014
dc.contributor.authorGulbas, Gazi
dc.contributor.authorTuran, Onur
dc.contributor.authorSarioglu, Nurhan
dc.contributor.authorDiken, Ozlem Ercen
dc.contributor.authorOgan, Nalan
dc.contributor.authorKadioglu, Esra Ekbic
dc.contributor.authorSuerdem, Mecit
dc.date.accessioned2021-11-01T15:03:00Z
dc.date.available2021-11-01T15:03:00Z
dc.date.issued2019
dc.department[Belirlenecek]
dc.description.abstractIntroduction Chronic obstructive pulmonary disease (COPD) is associated with increased cardiovascular morbidity and mortality. Carotid intima-media thickness (CIMT) is a noninvasive method assessing atherosclerosis. Objective It was aimed to determine relationship and survival between COPD and CIMT. Methods CIMT was measured using Doppler ultrasound (USG) in 668 stable COPD patients at 24 centers. Patients were followed-up for 2 years. Results There were 610 patients who completed the study. There were 200 patients CIMT with <0.78 mm (group 1), and 410 with CIMT >= 0.78 mm (group 2). There was a significant difference at the parameters of age, gender, smoking load, biomass exposure, GOLD groups and degree of airway obstruction (FEV1) between groups 1 and 2. Our results revealed positive correlations between mean CIMT and age, smoking load (pack-years), biomass exposure (years), exacerbation rate (last year), duration of hypertension (years) and cholesterol level; negative correlations between CIMT and FEV1 (P < 0.05). According to logistic regression model, compared with group A, risk of CIMT increase was 2.2-fold in group B, 9.7-fold in group C and 4.4-fold in group D (P < 0.05). Risk of CIMT increase was also related with cholesterol level (P < 0.05). Compared with infrequent exacerbation, it was 2.8-fold in the patients with frequent exacerbation (P < 0.05). The mean survival time was slightly higher in group 1, but not significant (23.9 vs 21.8 months) (P > 0.05). Conclusion This study is the first regarding CIMT with combined GOLD assessment groups. It has revealed important findings supporting the increase in atherosclerosis risk in COPD patients. We recommend Doppler USG of the carotid artery in COPD patients at severe stages.
dc.identifier.doi10.1111/crj.13024
dc.identifier.endpage399en_US
dc.identifier.issn1752-6981
dc.identifier.issn1752-699X
dc.identifier.issue6en_US
dc.identifier.pmid30942958
dc.identifier.scopus2-s2.0-85066013688
dc.identifier.scopusqualityQ3
dc.identifier.startpage391en_US
dc.identifier.urihttps://doi.org/10.1111/crj.13024
dc.identifier.urihttps://hdl.handle.net/11491/6907
dc.identifier.volume13en_US
dc.identifier.wosWOS:000470921200006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofClinical Respiratory Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcarotid intima-mediaen_US
dc.subjectCOPDen_US
dc.subjectexacerbationen_US
dc.subjectsurvivalen_US
dc.titleCarotid intima-media thickness in chronic obstructive pulmonary disease and survival: A multicenter prospective study
dc.typeArticle

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