The Prevalence of Mixed Genotype Infections in Turkish Patients with Hepatitis C: a Multicentered Assessment

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dc.authoridcekin, yesim / 0000-0003-4393-5618
dc.authoridgureser, Ayse semra / 0000-0002-6455-5932
dc.authoridAltindis, Mustafa / 0000-0003-0411-9669
dc.authoridAKTAS, OSMAN / 0000-0002-7762-4108
dc.authoridKarsligil, Tekin / 0000-0001-7672-3625
dc.authoridakyar, isin / 0000-0003-1115-0429
dc.authoridSayiner, Ayca / 0000-0001-6750-2353
dc.authorwosidcekin, yesim / AAL-9661-2020
dc.authorwosidgureser, Ayse semra / E-9513-2018
dc.authorwosidEce, Gulfem / AAN-7463-2020
dc.authorwosidAltindis, Mustafa / O-8413-2019
dc.authorwosidAKTAS, OSMAN / Z-1102-2019
dc.authorwosidKarsligil, Tekin / AAG-9204-2020
dc.authorwosidAYDIN, FARUK / AAL-6973-2021
dc.contributor.authorKulah, Canan
dc.contributor.authorAltindis, Mustafa
dc.contributor.authorAkyar, Isin
dc.contributor.authorGokahmetoglu, Selma
dc.contributor.authorSayiner, Arzu
dc.contributor.authorKaleli, Ilknur
dc.contributor.authorComert, Fusun
dc.date.accessioned2021-11-01T15:03:00Z
dc.date.available2021-11-01T15:03:00Z
dc.date.issued2019
dc.department[Belirlenecek]
dc.description.abstractBackground: HCV virus infections are one of the major health problems in the world that can cause cirrhosis and liver cancer at a higher rate than other hepatitis data. The aim of this study was to determine the prevalence of mixed infections with different HCV genotypes in Turkey and also to evaluate the current HCV genot pe and subtype distributions by a multicentered assessment. Methods: The HCV genotype data of 17,578 hepatitis C patients collected from 23 centers from different geographic regions covering all Turkey were collected. The data included information about the HCV genotypes in the last 10 years (bail een 2007 and 2016), demographic properties of the patients and the methods/systems used to determine the genotypes. Results: Two hundred twenty-eight of the patients (1.3%) had mixed genotype. The most common mixed genotype combination was 1b + 4 (0.83%) followed by 1a + 1b (0.26%). Genotype distribution varies according to geographical regions. However, genotype 1 (82.92%) was the most common genotype in all regions and all years. This was followed by genotype 3 (7.07%) and genotype 4 (5.43%). A variety of methods were used by the centers including sequencing, pyrosequencing, real-time PCR, in-house RFLP, reverse hybridization (LIPA), and hybridization. Conclusions: Infection with mixed HCV genotypes in Turkey is uncommon. Genotype distribution varies according to geographic regions; the most common genotype 1 is encountered all oN er the country, while genotypes 3 and 4 are only in some of the centers. Since there is limited information about mixed HCV infection, further investigations are needed to determine the clinical importance of mixed HCV infection.
dc.identifier.doi10.7754/Clin.Lab.2018.180824
dc.identifier.endpage490en_US
dc.identifier.issn1433-6510
dc.identifier.issue4en_US
dc.identifier.pmid30969089
dc.identifier.scopus2-s2.0-85064721774
dc.identifier.scopusqualityQ3
dc.identifier.startpage485en_US
dc.identifier.urihttps://doi.org/10.7754/Clin.Lab.2018.180824
dc.identifier.urihttps://hdl.handle.net/11491/6906
dc.identifier.volume65en_US
dc.identifier.wosWOS:000463988900008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherClin Lab Publ
dc.relation.ispartofClinical Laboratory
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHCVen_US
dc.subjectgenotypesen_US
dc.subjectmixed genotypesen_US
dc.subjectTurkeyen_US
dc.subjectmulticenteren_US
dc.titleThe Prevalence of Mixed Genotype Infections in Turkish Patients with Hepatitis C: a Multicentered Assessment
dc.typeArticle

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