Chronic immobilization stress induces anxiety-related behaviors and affects brain essential minerals in male rats

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dc.authorscopusid56351486100
dc.authorscopusid57200694247
dc.authorscopusid55971751500
dc.authorscopusid11940176800
dc.authorscopusid57200699458
dc.authorscopusid57201084630
dc.authorscopusid57196056331
dc.contributor.authorSahin, Z.
dc.contributor.authorOzkurkculer, A.
dc.contributor.authorKalkan, O.F.
dc.contributor.authorOzkaya, A.
dc.contributor.authorKoç, Aynur
dc.contributor.authorKoca, R.O.
dc.contributor.authorKutlu, S.
dc.date.accessioned2021-11-01T14:51:41Z
dc.date.available2021-11-01T14:51:41Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractAlterations of essential elements in the brain are associated with the pathophysiology of many neuropsychiatric disorders. It is known that chronic/overwhelming stress may cause some anxiety and/or depression. We aimed to investigate the effects of two different chronic immobilization stress protocols on anxiety-related behaviors and brain minerals. Adult male Wistar rats were divided into 3 groups as follows (n = 10/group): control, immobilization stress-1 (45 minutes daily for 7-day) and immobilization stress-2 (45 minutes twice a day for 7-day). Stress-related behaviors were evaluated by open field test and forced swimming test. In the immobilization stress-1 and immobilization stress-2 groups, percentage of time spent in the central area (6.38 ± 0.41% and 6.28 ± 1.03% respectively, p < 0.05) and rearing frequency (2.75 ± 0.41 and 3.85 ± 0.46, p < 0.01 and p < 0.05, respectively) were lower, latency to center area (49.11 ± 5.87 s and 44.92 ± 8.04 s, p < 0.01 and p < 0.01, respectively), were higher than the control group (8.65 ± 0.49%, 5.37 ± 0.44 and 15.3 ± 3.32 s, respectively). In the immobilization stress-1 group, zinc (12.65 ± 0.1 ppm, p < 0.001), magnesium (170.4 ± 1.7 ppm, p < 0.005) and phosphate (2.76 ± 0.1 ppm, p < 0.05) levels were lower than the control group (13.87 ± 0.16 ppm, 179.31 ± 1.87 ppm and 3.11 ± 0.06 ppm, respectively). In the immobilization stress-2 group, magnesium (171.56 ± 1.87 ppm, p < 0.05), phosphate (2.44 ± 0.07 ppm, p < 0.001) levels were lower, and manganese (373.68 ± 5.76 ppb, p < 0.001) and copper (2.79 ± 0.15 ppm, p < 0.05) levels were higher than the control group (179.31 ± 1.87 ppm, 3.11 ± 0.06 ppm, 327.25 ± 8.35 ppb and 2.45 ± 0.05 ppm, respectively). Our results indicated that 7-day chronic immobilization stress increased anxiety-related behaviors in both stress groups. Zinc, magnesium, phosphate, copper and manganese levels were affected in the brain. © 2020 Hogrefe Verlag.
dc.identifier.doi10.1024/0300-9831/a000682
dc.identifier.endpage8en_US
dc.identifier.issn0300-9831
dc.identifier.pmid32954971
dc.identifier.scopus2-s2.0-85091712885
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1024/0300-9831/a000682
dc.identifier.urihttps://hdl.handle.net/11491/6263
dc.identifier.wosWOS:000863480300006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherHogrefe Verlag GmbH & Co. KG
dc.relation.ispartofInternational Journal for Vitamin and Nutrition Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectanxietyen_US
dc.subjectbrainen_US
dc.subjectdepressionen_US
dc.subjectImmobilization stressen_US
dc.subjectmale raten_US
dc.subjectmineralen_US
dc.titleChronic immobilization stress induces anxiety-related behaviors and affects brain essential minerals in male rats
dc.typeArticle

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