A novel wound dressing material: Pullulan grafted copolymer hydrogel via UV copolymerization and crosslinking

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dc.authorid0000-0002-8036-8678
dc.authorid0000-0003-1535-4381
dc.authorscopusid11139563000
dc.authorscopusid37112868500
dc.authorscopusid57218916328
dc.contributor.authorMert Balaban, Hümeyra
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorDamar, Hüdanur
dc.date.accessioned2021-01-18T07:43:30Z
dc.date.available2021-01-18T07:43:30Z
dc.date.issued2020en_US
dc.departmentHitit Üniversitesi, Mühendislik Fakültesi, Polimer Malzeme Mühendisliği Bölümü
dc.description.abstractThis study presents the preparation and characterization of pullulan grafted copolymer hydrogel as a new wound dressing material. In this regard, pullulan grafted copolymer hydrogel (PGH) was prepared via UV copolymerization and crosslinking reactions of acrylic acid and itaconic acid onto pullulan. Ampicillin sodium salt loaded PGH was also prepared in the same manner with the addition of the drug in the reaction medium. In-vitro drug release experiments showed that 67% of the loaded drug was released from the PGHs after 7 days. Swelling studies performed at different pH conditions confirmed the high swelling capacities of PGHs (i.e., 700%). Besides, MTT assay showed that L929 cell viability could overpass 80% for PGHs. These results revealed that the prepared non-cytotoxic PGHs are promising candidates for wound dressing applications.
dc.identifier.citationMert, H., Özkahraman, B., Damar, H. (2020). A novel wound dressing material: Pullulan grafted copolymer hydrogel via UV copolymerization and crosslinking. Journal of Drug Delivery Science and Technology, 60.
dc.identifier.doi10.1016/j.jddst.2020.101962
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.issue60en_US
dc.identifier.scopus2-s2.0-85090723329
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/11491/5830
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2020.101962
dc.identifier.wosWOS:000601050500006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖzkahraman, Bengi
dc.language.isoen
dc.publisherEditions de Sante
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPullulanen_US
dc.subjectHydrogelen_US
dc.subjectDrug Deliveryen_US
dc.subjectWound Dressingen_US
dc.subjectAntibiotic Releaseen_US
dc.titleA novel wound dressing material: Pullulan grafted copolymer hydrogel via UV copolymerization and crosslinking
dc.typeArticle

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