Self-assembly of an organocatalyst for the enantioselective synthesis of Michael adducts and ?-aminoxy alcohols in a nonpolar medium
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Tarih
2013
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A proline-thiourea host-guest complex is described as a self-assembled organocatalyst for the enantioselective Michael addition of aldehydes to nitroolefins and for the asymmetric ?-aminoxylation of both aldehydes and ketones. The Michael adducts were obtained in good yields of up to 80%, high diastereoselectivities of up to 5:95, and high enantiomeric excesses of up to 98%. The optically active aminoxy alcohols were synthesized in 60-85% yields with 94-99% enantiomeric excesses after reduction of the ?-oxidation products using NaBH4. © 2013 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
[Belirlenecek]
Kaynak
Tetrahedron Asymmetry
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
24
Sayı
19
Künye
Demir, A. S., Basçeken, S. (2013). Self-assembly of an organocatalyst for the enantioselective synthesis of Michael adducts and ?-aminoxy alcohols in a nonpolar medium. Tetrahedron: Asymmetry, 24(19), 1218-1224.
