Electrochemical Determination and In Silico Studies of Fludarabine on NH2 Functionalized Multiwalled Carbon Nanotube Modified Glassy Carbon Electrode

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dc.authoridTASKIN TOK, Tugba / 0000-0002-0064-8400
dc.authoridTok, Tugba Taskin / 0000-0002-0064-8400
dc.authoridDOGAN-TOPAL, BURCU / 0000-0002-6455-4577
dc.authorwosidTASKIN TOK, Tugba / A-8885-2016
dc.authorwosidTOPAL, BURCU DOGAN / AAH-6335-2020
dc.authorwosidTok, Tugba Taskin / M-5740-2019
dc.contributor.authorDogan-Topal, Burcu
dc.contributor.authorBakirhan, Nurgul K.
dc.contributor.authorTok, Tugba Taskin
dc.contributor.authorOzkan, Sibel A.
dc.date.accessioned2021-11-01T15:05:07Z
dc.date.available2021-11-01T15:05:07Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractA sensitive voltammetric technique has been developed for the determination of Fludarabine using amine-functionalized multi walled carbon nanotubes modified glassy carbon electrode (NH2-MWCNTs/GCE). Molecular dynamics simulations, an in silico technique, were employed to examine the properties including chemical differences of Fludarabine- functionalized MWCNT complexes. The redox behavior of Fludarabine was examined by cyclic, differential pulse and square wave voltammetry in a wide pH range. Cyclic voltammetric investigations emphasized that Fludarabine is irreversibly oxidized at the NH2-MWCNTs/GCE. The electrochemical behavior of Fludarabine was also studied by cyclic voltammetry to evaluate both the kinetic (k(s) and E-a) and thermodynamic (Delta H, Delta G and Delta S) parameters on NH2-MWCNTs/GCE at several temperatures. The mixed diffusion-adsorption controlled electrochemical oxidation of Fludarabine revealed by studies at different scan rates. The experimental parameters, such as pulse amplitude, frequency, deposition potential optimized for square-wave voltammetry. Under optimum conditions in phosphate buffer (pH 2.0), a linear calibration curve was obtained in the range of 2x10(-7) M-4x10(-6) M solution using adsorptive stripping square wave voltammetry. The limit of detection and limit of quantification were calculated 2.9x10(-8) M and 9.68x10(-8) M, respectively. The developed method was applied to the simple and rapid determination of Fludarabine from pharmaceutical formulations.
dc.identifier.doi10.1002/elan.201900347
dc.identifier.endpage49en_US
dc.identifier.issn1040-0397
dc.identifier.issn1521-4109
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85070877887
dc.identifier.scopusqualityQ2
dc.identifier.startpage37en_US
dc.identifier.urihttps://doi.org/10.1002/elan.201900347
dc.identifier.urihttps://hdl.handle.net/11491/7119
dc.identifier.volume32en_US
dc.identifier.wosWOS:000480999400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofElectroanalysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFludarabineen_US
dc.subjectnanosensoren_US
dc.subjectmulti walled carbon nanotubesen_US
dc.subjectthermodynamicen_US
dc.subjectmolecular dynamicsen_US
dc.titleElectrochemical Determination and In Silico Studies of Fludarabine on NH2 Functionalized Multiwalled Carbon Nanotube Modified Glassy Carbon Electrode
dc.typeArticle

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