Correlation of molecular biomarker concentrations between synovial fluid and saliva of the patients with temporomandibular disorders

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dc.authoridYaman, Deniz / 0000-0002-1492-6897
dc.contributor.authorYaman, Deniz
dc.contributor.authorAlpaslan, Cansu
dc.contributor.authorAkca, Gülçin
dc.contributor.authorAvcı, Emre
dc.date.accessioned2021-11-01T15:05:07Z
dc.date.available2021-11-01T15:05:07Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractObjectives The synovial membrane and fluid are involved in the pathogenesis of temporomandibular joint (TMJ) disorders. This study aims to assess the relationship between matrix metalloproteinase-2 (MMP-2), chemerin and prostaglandin (PGE(2)) levels in the synovial fluid (SF) and saliva of patients with TMJ disorder regarding their role in inflammation and the value of being a candidate for predictive biomarkers in the disease. Also, it is aimed to find out whether chemerin's main function triggers the formation inflammatory cytokine markers in the associated area. Materials and methods Thirty-two samples of SF and saliva were obtained from patients with disc displacement without reduction with limited opening (DDWORwLO). Mann-Whitney-U test was used for the comparisons of the biomarker levels in SF and saliva. The correlation between chemerin and BMI (Body Mass Index) is analyzed by non-parametric Spearman's rho correlation coefficient. Results For all of the three biomarkers, statistically significant differences were found between SF and saliva. An unexpectedly high level expression of chemerin was observed in SF. A statistically significant, positive correlation was observed between PGE(2) -MMP-2, and chemerin-PGE(2) in saliva, chemerin and MMP-2 in SF, respectively (p = 0.031, r = 0.382 / p = 0.039, r = 0.366 / p = 0.032, r = 0.379). A positive correlation was determined between saliva and SF levels of PGE(2) (p = 0.016, r = 0.421). Conclusions Chemerin, MMP-2, and PGE(2) can play a role as an inflammatory factor for the development of TMJ disorder.
dc.identifier.doi10.1007/s00784-020-03310-8
dc.identifier.endpage4461en_US
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.issue12en_US
dc.identifier.pmid32385657
dc.identifier.scopus2-s2.0-85084514628
dc.identifier.scopusqualityQ1
dc.identifier.startpage4455en_US
dc.identifier.urihttps://doi.org/10.1007/s00784-020-03310-8
dc.identifier.urihttps://hdl.handle.net/11491/7118
dc.identifier.volume24en_US
dc.identifier.wosWOS:000531145600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAvcı, Emre
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofClinical Oral Investigations
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTemporomandibular disorderen_US
dc.subjectSalivaen_US
dc.subjectSynovial fluiden_US
dc.subjectBiomarkersen_US
dc.titleCorrelation of molecular biomarker concentrations between synovial fluid and saliva of the patients with temporomandibular disorders
dc.typeArticle

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