Higher body mass index and larger waist circumference may be predictors of thyroid carcinoma in patients with Hürthle-cell lesion/neoplasm fine-needle aspiration diagnosis
[ X ]
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Blackwell Publishing Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective High body mass index (BMI) has been found to be associated with raised thyroid cancer risk, particularly in women. We examined the associations for BMI and waist circumference (WC) with thyroid cancer risk among women with Hürthle?cell lesion/neoplasm (HLN) on fine?needle aspiration biopsy (FNAB) with the hypothesis that BMI and WC could guide the management of these challenging indeterminate lesions. Methods This cross?sectional study included 224 women with HLN who underwent thyroidectomy. In all patients, TSH and thyroid auto?antibodies were evaluated, and thyroid nodule features were recorded. Patients were grouped according to BMI (<30 or ?30 kg/m2) and WC (<88 or ?88 cm). Relationships of thyroid cancer with BMI and WC were assessed using logistic regression analysis. Results Mean weight, BMI (31·26 ± 5·1 vs 26·47 ± 5·9, P < 0·001), WC (98·23 ± 7·6 vs 86·18 ± 11, P = 0·001), and proportion of patients with high BMI (?30 kg/m2) (65·9 vs 33·8%, P < 0·001) or large WC (?88 cm) (84·1 vs 47·9%, P < 0·001) were significantly higher in malignant group compared to benign group. In regression analysis, BMI and WC significantly associated with existence of malignancy. Malignancy risk was 3·819?fold higher (95% CI: 2·068–7·054) in BMI?30 kg/m2 group compared to BMI<30 kg/m2, which was independent of TSH and age. Large WC was also associated with increased risk (OR = 5·593, 95% CI: 2·736–11·434). Baseline tumour characteristics were similar according to BMI and WC groups. Conclusions A great BMI and large WC were associated with higher thyroid cancer risk in patients with FNAB diagnosis of HLN. Further studies are needed to use BMI or WC in the management of patients with HLN.
Açıklama
Anahtar Kelimeler
[Belirlenecek]
Kaynak
Clinical Endocrinology
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
83
Sayı
3
Künye
Arduç, A., Doğan, B., Tuna, M. M., Ateş Tütüncü, Y., Işık, S., Berker, D., Güler, S. (2015). Higher body mass index and larger waist circumference may be predictors of thyroid carcinoma in patients with Hürthle?cell lesion/neoplasm fine?needle aspiration diagnosis. Clinical Endocrinology, 83(3), 405-411.
