Assessment of endothelial dysfunction with adhesion molecules in patients with celiac disease

dc.contributor.authorComba, Atakan
dc.contributor.authorÇaltepe, Gönül
dc.contributor.authorYanık, Keramettin
dc.contributor.authorGör, Ufuk
dc.contributor.authorYüce, Özlem
dc.contributor.authorKalaycı, Ayhan G.
dc.date.accessioned2019-05-10T09:40:04Z
dc.date.available2019-05-10T09:40:04Z
dc.date.issued2016
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractObjectives: Celiac disease (CD) is a systemic immune disorder. We assessed serum levels of adhesion molecules as a marker of endothelial dysfunction in patients with CD at first diagnosis and in those on a glutenfree diet. Methods: Sixty-five patients with CD (mean age 6.74±4.6 years) and 51 age- and sex-matched control patients participated in the present casecontrolled, prospective clinical study. Serum levels of vascular adhesion molecule-1, intercellular adhesion molecule-1, endothelial selectin, vascular endothelial cadherin, high-sensitivity C-reactive protein, and homocysteine levels were measured. Results: Average soluble vascular adhesion molecule-1 (CD vs control group: 1320±308 vs 1120±406 ng/mL, P=0.006), soluble intercellular adhesion molecule-1 (336±99 vs 263±67 ng/mL, P=0.025), and soluble endothelial selectin (113.9±70 vs 76.9±32 ng/mL, P=0.007) levels were significantly higher in cases of newly diagnosed CD than in the control group. Soluble vascular adhesion molecule-1 (1050±190 ng/mL) and soluble endothelial selectin (68.7±45 ng/mL) levels in patients with CD, who were fully compliant with a gluten-free diet, were significantly lower than that in those newly diagnosed as having CD (P=0.003 and P=0.0012, respectively). Conclusions: These results show that serum adhesion molecule levels are higher in patients with CD. Some of the risks associated with endothelial dysfunction may be related to CD and these risks can be reduced with an appropriate and fully controlled diet. Copyright © 2016 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.
dc.identifier.citationComba, A., Çaltepe, G., Yanık, K., Gör, U., Yüce, Ö., Kalaycı, A. G. (2016). Assessment of endothelial dysfunction with adhesion molecules in patients with celiac disease. Journal of Pediatric Gastroenterology and Nutrition, 63(2), 247-252.
dc.identifier.doi10.1097/MPG.0000000000001138
dc.identifier.endpage252en_US
dc.identifier.issn0277-2116
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage247en_US
dc.identifier.urihttps://doi.org/10.1097/MPG.0000000000001138
dc.identifier.urihttps://hdl.handle.net/11491/837
dc.identifier.volume63en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherLippincott Williams and Wilkins
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdhesion Moleculesen_US
dc.subjectCeliac Diseaseen_US
dc.subjectChilden_US
dc.subjectEndothelial Dysfunctionen_US
dc.titleAssessment of endothelial dysfunction with adhesion molecules in patients with celiac disease
dc.typeArticle

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