Relationship of serum asymmetric dimethylarginine levels with inflammation and cardiac functions in autosomal dominant polycystic kidney disease

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dc.contributor.authorDoğan, İbrahim
dc.contributor.authorAltuner, Şakir
dc.contributor.authorKahvecioğlu, Serdar
dc.contributor.authorHünük, Ahmet
dc.contributor.authorEser, Barış
dc.contributor.authorYayar, Özlem
dc.contributor.authorKurtoğlu, Ünal
dc.contributor.authorBayol, Hakan
dc.date.accessioned2019-05-13T09:03:04Z
dc.date.available2019-05-13T09:03:04Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractOBJECTIVE: Most deaths in autosomal dominant polycystic kidney disease (ADPKD) are attributable to cardiovascular disease (CVD). The relationship between serum asymmetric dimethylarginine (ADMA) and CVD has been investigated. We aimed to search the relationship between serum ADMA, atherosclerosis, inflammation and cardiac functions in ADPKD. MATERIAL and METHODS: Fifty-seven ADPKD patients and 23 healthy control subjects were enrolled. Carotid artery intima-media thickness (CIMT) and echocardiographic measurements were performed. ADMA, inflammatory markers, Neutrophil Count/Lymphocyte Count (NLR), echocardiographic findings and CIMT values were compared between the groups. Correlation analyses were performed. RESULTS: ADMA levels were lower in patients compared to controls [10106 ng/L (2010-60000) vs. 20161 ng/L (2902-60000), p=0.006]. CIMT was 0.67±0.03 mm in the patient group and 0.62±0.03 mm in the control group (p>0.05). In the patient group, left ventricular mass (LVM), left ventricular mass index (LVMI), left atrial diameter (LAD) and left ventricular end-diastolic diameter (LVEDD) values were higher (p<0.001, p<0.001, p<0.05, p<0.01). NLR was 2.0 (0.96-13) in the patient group and 1.6 (0.81-6.06) in the control group (p<0.01). Serum ADMA levels were negatively correlated with CIMT and LAD (p<0.05, p<0.001). CONCLUSION: Serum ADMA levels were found to be low in ADPKD patients. Additional studies are needed to determine the possible affect of ADMA on atherosclerosis and inflammation in early stage of ADPKD. © 2018 Turkish Society of Nephrology. All rights reserved.
dc.identifier.citationAltuner, Ş., Hünük, A., Eser, B., Yayar, Ö., Kurtoğlu, Ü., Bayol, H. (2018). Relationship of serum asymmetric dimethylarginine levels with inflammation and cardiac functions in autosomal dominant polycystic kidney disease. Turkish Nephrology, Dialysis and Transplantation Journal, 27(1), 68-75.
dc.identifier.doi10.5262/tndt.2018.1001.05
dc.identifier.endpage75en_US
dc.identifier.issn1300-7718
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage68en_US
dc.identifier.urihttps://doi.org/10.5262/tndt.2018.1001.05
dc.identifier.urihttps://hdl.handle.net/11491/1395
dc.identifier.volume27en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTurkish Society of Nephrology
dc.relation.ispartofTurkish Nephrology, Dialysis and Transplantation Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAsymmetric Dimethyl Arginineen_US
dc.subjectAtherosclerosisen_US
dc.subjectAutosomal Dominant Polycystic Kidney Diseaseen_US
dc.subjectCarotid Artery Intima-Media Thicknessen_US
dc.subjectInflammationen_US
dc.titleRelationship of serum asymmetric dimethylarginine levels with inflammation and cardiac functions in autosomal dominant polycystic kidney disease
dc.typeArticle

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