Safety of once-or twice-daily dosing of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with nonvalvular atrial fibrillation: a NOAC-TR study

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dc.contributor.authorEmren, Sadık Volkan
dc.contributor.authorZoghi, Mehdi
dc.contributor.authorBerilgen, Rida
dc.contributor.authorÖzdemir, İbrahim Halil
dc.contributor.authorÇelik, Oğuzhan
dc.contributor.authorÇetin, Nurullah
dc.contributor.authorEnhoş, Asım
dc.contributor.authorKöseoğlu, Cemal
dc.contributor.authorAkyüz, Abdurrahman
dc.contributor.authorDoğan, Volkan
dc.contributor.authorLevent, Fatih
dc.contributor.authorDereli, Yüksel
dc.contributor.authorDoğan, Tolga
dc.contributor.authorBaşaran, Özcan
dc.contributor.authorKaraca, Ilgın
dc.contributor.authorKaraca, Özkan
dc.contributor.authorOtlu, Yılmaz Ömür
dc.contributor.authorÖzmen, Çağlar
dc.contributor.authorCoşar, Selvi
dc.contributor.authorSümerkan, Mutlu Çağan
dc.contributor.authorGürsul, Erdal
dc.contributor.authorİnci, Sinan
dc.contributor.authorOnrat, Ersel
dc.contributor.authorErgene, Oktay
dc.date.accessioned2019-05-13T09:04:04Z
dc.date.available2019-05-13T09:04:04Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractOnce-daily dosing of non-vitamin K antagonist oral anticoagulants (NOACs) may increase patient adherence to treatment but may also be associated with a higher risk of bleeding. In this study, we investigated the adherence to once-or twice-daily dosing of NOACs and the risk of bleeding in nonvalvular atrial fibrillation (NVAF) patients. This multicenter cross-sectional study, conducted between 1 September 2015 and 28 February 2016, included 2214 patients receiving NOACs for at least 3 months, due to NVAF. Patients receiving once-daily or twice-daily NOAC doses were 1:1 propensity score matched for baseline demographic characteristics and the presence of other diseases. The medication adherence was assessed by the 8-item Morisky Medication Adherence Scale. Risk factors were investigated in relation to minor and major bleeding. The mean age of patients was 71 ± 10 years, and 53% of the patients were women. The medication adherence was lower in patients receiving twice-daily NOAC doses compared to once-daily-dose group (47% versus 53%, p = 0.001), and there was no difference between the groups in terms of minor (15% versus 16%, p = 0.292) and major bleeding (3% versus 3%, p = 0.796). Independent risk factors for bleeding were non-adherence to medication (OR: 1.62, 95% CI: 1.23–2.14, p = 0.001), presence of 3 or more other diseases (OR: 10.3, 95% CI: 5.3–20.3, p < 0.001), and HAS-BLED (Hypertension, Abnormal renal and liver function, Stroke, Bleeding, Labile INR, Elderly, Drugs or alcohol) score (OR: 4.84, 95% CI: 4.04–5.8, p < 0.001). In summary, the once-daily dose of NOACs was associated with increased patient adherence to medication, while it was not associated with bleeding complications. © 2018 ABMSFBIH.
dc.identifier.citationEmren, S. V., Zoghi, M., Berilgen, R., Özdemir, İ. H., Çelik, O., Çetin, N., ... & Levent, F. (2018). Safety of once-or twice-daily dosing of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with nonvalvular atrial fibrillation: a NOAC-TR study. Bosnian Journal of Basic Medical Sciences, 18(2), 185-190.
dc.identifier.doi10.17305/bjbms.2017.2279
dc.identifier.endpage190en_US
dc.identifier.issn1512-8601
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage185en_US
dc.identifier.urihttps://doi.org/10.17305/bjbms.2017.2279
dc.identifier.urihttps://hdl.handle.net/11491/1582
dc.identifier.volume18en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAssociation of Basic Medical Sciences of FBIH
dc.relation.ispartofBosnian Journal of Basic Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBleedingen_US
dc.subjectMedication Adherenceen_US
dc.subjectNOACsen_US
dc.subjectNon-Vitamin K Antagonist Oral Anticoagulantsen_US
dc.subjectNonvalvular Atrial Fibrillationen_US
dc.subjectNVAFen_US
dc.subjectSelf-Reporten_US
dc.subjectDaily Dosingen_US
dc.titleSafety of once-or twice-daily dosing of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with nonvalvular atrial fibrillation: a NOAC-TR study
dc.typeArticle

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