Evaluating the Effect of Intravitreal Ranibizumab on Retrobulbar Hemodynamics by Color Doppler Ultrasonography in Neovascular AMD

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dc.authoridCAKMAK, HASAN BASRI / 0000-0001-6877-8773
dc.authorwosidCagil, Nurullah / AAG-1401-2019
dc.contributor.authorRaza, Sabri
dc.contributor.authorErgun, Sule Berk
dc.contributor.authorToklu, Yasin
dc.contributor.authorCakmak, Hasan Basri
dc.contributor.authorIpek, Ali
dc.contributor.authorCagil, Nurullah
dc.date.accessioned2021-11-01T15:02:57Z
dc.date.available2021-11-01T15:02:57Z
dc.date.issued2019
dc.department[Belirlenecek]
dc.description.abstractBACKGROUND AND OBJECTIVE: To evaluate changes in retrobulbar blood flow by using color Doppler ultrasonography (CDUS) after intravitreal ranibizumab injection in patients with neovascular age-related macular degeneration (AMD). PATIENTS AND METHODS: Eighteen patients who had undergone intravitreal ranibizumab (0.05 mg/0.05 mL) injection due to choroidal neovascular membrane (CNVM) were included in the study. Contralateral eyes of the patients were also analyzed. Peak systolic velocity (PSV), end diastolic velocity (EDV), pulsatility index (PI), and resistivity index (RI) were measured from the ophthalmic artery (OA), central retinal artery (CRA), lateral posterior ciliary artery (LPCA), and medial posterior ciliary artery (MPCA) for all patients pre-injection, and at 1 day, 1 week, and 1 month after ranibizumab injection. RESULTS: The mean age of the 18 patients included in the study was 66.94 years (+/- 8.3 years). Of these 10 patients, eight were female and 10 were male. After Bonferroni's correction for multiple comparisons was carried out, there were significant differences only in some values of LPCA; these included the decrease in EDV and an increase in PI values of LPCA between the pre-injection and post-injection of the first month measurements in uninjected eyes (P = .002, P = .002), and a decrease in PI value of LPCA between post-injection first day and first week measurements in injected eyes (P = .004). There were no statistically significant differences in other parameters. CONCLUSION: Ocular blood flow velocities may change after intravitreal ranibizumab injection in patients with CNVM.
dc.identifier.doi10.3928/23258160-20190703-05
dc.identifier.endpage443en_US
dc.identifier.issn2325-8160
dc.identifier.issn2325-8179
dc.identifier.issue7en_US
dc.identifier.pmid31344243
dc.identifier.scopus2-s2.0-85070632319
dc.identifier.scopusqualityQ3
dc.identifier.startpage437en_US
dc.identifier.urihttps://doi.org/10.3928/23258160-20190703-05
dc.identifier.urihttps://hdl.handle.net/11491/6884
dc.identifier.volume50en_US
dc.identifier.wosWOS:000477743100006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherSlack Inc
dc.relation.ispartofOphthalmic Surgery Lasers & Imaging Retina
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject[No Keywords]en_US
dc.titleEvaluating the Effect of Intravitreal Ranibizumab on Retrobulbar Hemodynamics by Color Doppler Ultrasonography in Neovascular AMD
dc.typeArticle

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