Can the negative effects of ketamine abuse on female genital organs be prevented by nimesulide? An experimental study

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dc.authoridOnat, Taylan / 0000-0002-8920-1444
dc.authorwosidOnat, Taylan / AAX-2299-2020
dc.authorwosidYildirim, Engin / AAZ-2330-2021
dc.authorwosidKaplan, Selcuk / ABB-7529-2020
dc.contributor.authorTurkler, Can
dc.contributor.authorOnat, Taylan
dc.contributor.authorYildirim, Engin
dc.contributor.authorKaplan, Selcuk
dc.contributor.authorYazici, Gulce N.
dc.contributor.authorMammadov, Renad
dc.contributor.authorSunar, Mukadder
dc.date.accessioned2021-11-01T15:02:56Z
dc.date.available2021-11-01T15:02:56Z
dc.date.issued2019
dc.department[Belirlenecek]
dc.description.abstractThe objective of this study is to investigate the effects of nimesulide on ketamine-induced ovarian and uterine toxicity by biochemical and histopathological examinations. Ketamine is an anesthetic agent whose use leads to overproduction of catecholamines. Nimesulide is a cyclooxygenase-2 inhibitor, which has also been reported to exert a significant antioxidant effect. Wistar albino female rats were randomly divided into three groups as follows: ketamine group (60 mg/kg), ketamine (60 mg/kg)+nimesulide (50 mg/kg) group, and a healthy control group. Then, the biochemical levels and histopathological findings in the ovaries and uteri of the rats were examined for malondialdehyde, myeloperoxidase, total glutathione and superoxide dismutase. The study demonstrated that, in the uterine and ovarian tissues of rats that have been administered ketamine, there was a decrease in the levels of total glutathione and superoxide dismutase, while malondialdehyde and myeloperoxidase was increased: however it was observed that these ratios were reversed in the ketamine+nimesulide group. It was also proved that the negative effects of ketamine can be corrected with nimesulide when the myometrial and endometrial thicknesses are compared. Antioxidants such as nimesulide may protect against the damage caused by ketamine to the genital organs in young women.
dc.identifier.doi10.4149/gpb_2019023
dc.identifier.endpage434en_US
dc.identifier.issn0231-5882
dc.identifier.issn1338-4325
dc.identifier.issue5en_US
dc.identifier.pmid31411575
dc.identifier.scopus2-s2.0-85073084441
dc.identifier.scopusqualityQ3
dc.identifier.startpage427en_US
dc.identifier.urihttps://doi.org/10.4149/gpb_2019023
dc.identifier.urihttps://hdl.handle.net/11491/6867
dc.identifier.volume38en_US
dc.identifier.wosWOS:000489614600007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherGeneral Physiol And Biophysics
dc.relation.ispartofGeneral Physiology And Biophysics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKetamineen_US
dc.subjectNimesulideen_US
dc.subjectOvarian toxicityen_US
dc.subjectRaten_US
dc.subjectUterine toxicityen_US
dc.titleCan the negative effects of ketamine abuse on female genital organs be prevented by nimesulide? An experimental study
dc.typeArticle

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