Possible Association of PER2/PER3 Variable Number Tandem Repeat Polymorphism Variants with Susceptibility and Clinical Characteristics in Pancreatic Cancer

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dc.authoridGumusay, Ozge / 0000-0002-6236-9829
dc.authoridDAGMURA, HASAN / 0000-0003-2289-5514
dc.authoridDUMAN, ESRA / 0000-0003-4209-3009
dc.authorwosidGumusay, Ozge / AAT-3435-2021
dc.authorwosidDAGMURA, HASAN / AAF-1861-2021
dc.contributor.authorDagmura, Hasan
dc.contributor.authorYigit, Serbulent
dc.contributor.authorNursal, Ayse Feyda
dc.contributor.authorDuman, Esra
dc.contributor.authorGumusay, Ozge
dc.date.accessioned2021-11-01T15:06:00Z
dc.date.available2021-11-01T15:06:00Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractObjective: Pancreatic cancer (PC) is a serious disease with poor outcomes, and its prevalence has been increasing steadily. The circadian rhythm (CR) is involved in multiple physiological events and maintains homeostasis. Alterations in the CR elevate the risk of developing cancer. The present case-control research was carried out to estimate the possible association between PERIOD2/PERIOD3 (PER2/PER3) gene variable number tandem repeat polymorphism (VNTR) variants and PC in the Turkish population. Materials and Methods: A total of 198 subjects (78 patients with PC and 120 healthy controls) were enrolled in this work. Genomic DNA was collected from peripheral blood mononuclear cells, and genotype analysis was performed using a polymerase chain reaction (PCR) method. Odds ratio (OR) with a 95% confidence interval (95% CI) was calculated using the chi(2) test. Results: The frequency of the 4R (4 repeats)/3R (3 repeats), 3R/3R genotypes, and 3R allele of PER2 VNTR in patients with PC was significantly higher than in the control group (p = 0003, p = 0.00004, respectively). PER2 VNTR 4/5 genotype was related to perineural invasion (p = 0.040). The genotype and allele distribution of PER3 VNTR variant did not show any statistical difference between the two groups (p > 0.05). PER2/PER3 VNTR 4/5-4R/3R combined genotype increased in the patient group (p = 0.013), while 4/5-4R/4R combined genotype was superior in the control group (p = 0.0001). Conclusions: Our work has indicated that PER2 VNTR 3R allele may play a crucial task in the pathogenesis of PC in Turkish patients, which may become a useful marker for predicting the development of PC. Furthermore, the PER2 VNTR genotype seems to be related to perineural invasion in PC.
dc.identifier.doi10.1089/gtmb.2020.0179
dc.identifier.endpage130en_US
dc.identifier.issn1945-0265
dc.identifier.issn1945-0257
dc.identifier.issue2en_US
dc.identifier.pmid33393850
dc.identifier.scopus2-s2.0-85100932924
dc.identifier.scopusqualityQ3
dc.identifier.startpage124en_US
dc.identifier.urihttps://doi.org/10.1089/gtmb.2020.0179
dc.identifier.urihttps://hdl.handle.net/11491/7466
dc.identifier.volume25en_US
dc.identifier.wosWOS:000606489600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofGenetic Testing And Molecular Biomarkers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectpancreasen_US
dc.subjectcanceren_US
dc.subjectPER2en_US
dc.subjectPER3en_US
dc.subjectPCRen_US
dc.subjectVNTRen_US
dc.titlePossible Association of PER2/PER3 Variable Number Tandem Repeat Polymorphism Variants with Susceptibility and Clinical Characteristics in Pancreatic Cancer
dc.typeArticle

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