Determination of thiol/disulphide homeostasis in type 1 diabetes mellitus and the factors associated with thiol oxidation

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dc.contributor.authorAteş, İhsan
dc.contributor.authorKaplan, Mustafa
dc.contributor.authorYüksel, Mahmut
dc.contributor.authorMeşe, Duygu
dc.contributor.authorAlışık, Murat
dc.contributor.authorErel, Özcan
dc.contributor.authorYılmaz, Nisbet
dc.contributor.authorGüler, Serdar
dc.date.accessioned2019-05-13T09:08:40Z
dc.date.available2019-05-13T09:08:40Z
dc.date.issued2016
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractIn this study, we aimed to examine dynamic thiol/disulfide homeostasis in type 1 diabetes mellitus (T1DM) and identify the factors associated with thiol oxidation. Thirty-eight subjects (18 male, 20 female) diagnosed with T1DM and 38 (17 male, 21 female) healthy volunteers without any known diseases were included in the study. Thiol/disulfide homeostasis concentrations were measured by a newly developed method (Erel & Neselioglu) in this study. After native thiol, total thiol and disulfide levels were determined; measures such as disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol were calculated. In T1DM patients, compared to the control group, disulfide (p = 0.024), disulfide/native thiol (p < 0.001), and disulfide/total thiol (p < 0.001) were determined higher, while native thiol (p = 0.004) and total thiol (p < 0.001) levels were much lower. In the patient group, a positive correlation was determined between c-reactive protein (r = 325, p = 0.007; r = 316, p = 0.010, respectively), fasting blood glucose (r = 279, p = 0.018; r = 251, p = 0.035, respectively), and glycosylated hemoglobin (r = 341, p = 0.004; r = 332, p = 0.005, respectively) and rates of disulfide/native thiol and disulfide/total thiol. We determined that thiol oxidation increase in T1DM patients compared to the control group. We thought that hyperglycemia and chronic inflammation might be the major cause of increase in oxide thiol form. In order to determine the relationship between the status of autoimmunity and dynamic thiol/disulfide in T1DM, dynamic thiol/disulfide homeostasis in newly diagnosed-antibody positive-T1DM patients is required to be investigated. © 2015, Springer Science+Business Media New York.
dc.identifier.citationAteş, İ., Kaplan, M., Yüksel, M., Meşe, D., Alışık, M., Erel, Ö., Yılmaz, N., Güler, S. (2016). Determination of thiol/disulphide homeostasis in type 1 diabetes mellitus and the factors associated with thiol oxidation. Endocrine, 51(1), 47-51.
dc.identifier.doi10.1007/s12020-015-0784-6
dc.identifier.endpage51en_US
dc.identifier.issn1355-008X
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage47en_US
dc.identifier.urihttps://doi.org/10.1007/s12020-015-0784-6
dc.identifier.urihttps://hdl.handle.net/11491/2032
dc.identifier.volume51en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherHumana Press Inc.
dc.relation.ispartofEndocrine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAutoimmunityen_US
dc.subjectChronic Inflammationen_US
dc.subjectHyperglycemiaen_US
dc.subjectOxidative Stressen_US
dc.subjectSulfideen_US
dc.titleDetermination of thiol/disulphide homeostasis in type 1 diabetes mellitus and the factors associated with thiol oxidation
dc.typeArticle

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